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小鼠Eβ2基因：一种具有有限种内多态性和异常转录模式的II类主要组织相容性复合体β基因。

The mouse E beta 2 gene: a class II MHC beta gene with limited intraspecies polymorphism and an unusual pattern of transcription.

作者信息

Braunstein N S, Germain R N

出版信息

EMBO J. 1986 Oct;5(10):2469-76. doi: 10.1002/j.1460-2075.1986.tb04523.x.

DOI:10.1002/j.1460-2075.1986.tb04523.x
PMID:3780666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1167141/
Abstract

Analysis of genomic clones containing the E beta 2 region from the mouse major histocompatibility complex (MHC) reveals a gene that is similar to conventional class II beta genes in its overall organization and sequence but unusual in that it shows limited intraspecies allelic polymorphism. Like the conventional class II beta genes, the E beta 2 gene is transcriptionally active in a variety of B lymphoid cells. However, its transcripts consist of multiple polyadenylated species from 1.8 to 3.6 kb in size which are present at only approximately 1/20 the level of E beta 1 mRNA in the same cells. In addition, unlike other class II genes, E beta 2 transcription is not induced by gamma-interferon treatment of macrophage/monocyte tumor lines. These distinctive features suggest that the E beta 2 gene product may have a unique functional role, different from that of previously studied class II proteins.

摘要

对包含小鼠主要组织相容性复合体（MHC）Eβ2区域的基因组克隆进行分析，发现一个基因，其整体结构和序列与传统的II类β基因相似，但不同寻常的是，它在种内的等位基因多态性有限。与传统的II类β基因一样，Eβ2基因在多种B淋巴细胞中具有转录活性。然而，其转录本由大小从1.8到3.6 kb的多个多聚腺苷酸化物种组成，在相同细胞中的含量仅约为Eβ1 mRNA水平的1/20。此外，与其他II类基因不同，巨噬细胞/单核细胞肿瘤系经γ干扰素处理后，Eβ2转录不会被诱导。这些独特的特征表明，Eβ2基因产物可能具有独特的功能作用，不同于先前研究的II类蛋白质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5db/1167141/c70a29bbe199/emboj00173-0067-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5db/1167141/1a09526e2a99/emboj00173-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5db/1167141/c70a29bbe199/emboj00173-0067-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5db/1167141/1a09526e2a99/emboj00173-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5db/1167141/c70a29bbe199/emboj00173-0067-b.jpg

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