Hebei Medical University, Shijiazhuang, China.
Department of Obstetrics and Gynecology, the Frist Hospital of Hebei Medical University, Shijiazhuang, China.
Cell Mol Biol (Noisy-le-grand). 2023 Sep 30;69(9):195-200. doi: 10.14715/cmb/2023.69.9.30.
Cervical cancer (CC) is the most common human gynecological malignancy worldwide. Recently, accumulating evidences revealed the critical functions of miRNAs in the occurrence and development of cervical cancer. In our study, we aimed to demonstrate the function of miR-214-3p in regulating cell metastasis in cervical cancer. We showed low expression of miR-214-3p in cervical cancer cells and demonstrated downregulation of miR-214-3p promoted cervical cancer metastasis. Furthermore, THBS2 was identified as a novel target of miR-214-3p in cervical cancer cells. miR-214-3p suppressed THBS2 expression by directly targeting 3'UTR of THBS2, resulting in the inhibition of cell viability, invasion and migration. Taken together, the results implied inhibited effects of miR-214-3p on cervical cancer and provided new insight into potential ways for cervical cancer diagnosis and treatment.
宫颈癌（CC）是全球最常见的妇科恶性肿瘤。最近，越来越多的证据表明 miRNA 在宫颈癌的发生和发展中具有关键作用。在我们的研究中，我们旨在证明 miR-214-3p 在调节宫颈癌细胞转移中的功能。我们发现 miR-214-3p 在宫颈癌细胞中的表达较低，并证明下调 miR-214-3p 促进了宫颈癌的转移。此外，THBS2 被鉴定为宫颈癌细胞中 miR-214-3p 的一个新靶标。miR-214-3p 通过直接靶向 THBS2 的 3'UTR 抑制 THBS2 的表达，从而抑制细胞活力、侵袭和迁移。总之，这些结果暗示了 miR-214-3p 对宫颈癌的抑制作用，并为宫颈癌的诊断和治疗提供了新的思路。
