Jara-Ortega P, Ordoñez-Apolo F, Jara-Ortega N, Jara-Crespo F
Universidad Central del Ecuador, Quito, Ecuador.
Kruger School, Quito, Ecuador.
Rev Neurol. 2023 Oct 16;77(8):185-196. doi: 10.33588/rn.7708.2023145.
Cladophialophora bantiana is a filamentous fungus, known as a dematiaceous fungus because of the presence of melanin. This fungus is of clinical importance because it is neurotropic and causes cerebral phaeohyphomycosis.
The available scientific information on the development of cerebral phaeohyphomycosis caused by Cladophialophora bantiana was analysed by selecting articles from the PubMed, Scopus and Google Scholar databases that describe case reports of fungal infection by C. bantiana in adults, taking into account the analysis of the patients' symptomatology, clinical history and neuroanatomical damage, in addition to considering the mortality of the condition.
India and United States were the countries with most case reports, with 32 and 11 cases respectively. Moreover, in terms of neuroanatomical lesions, the majority of patients suffered mixed lesions (29%) and frontal lobe lesions (22%). In accordance with the patients' condition, the pathology has a mortality rate of 62%.
It is concluded that cerebral phaeohyphomycosis has a high mortality rate, there is no standardised treatment and, in most cases, the fungal infection of the brain is mixed and affects several different parts of it. Furthermore, if not diagnosed and treated in time, it can lead to the patients' death.
班替枝孢霉是一种丝状真菌，因其含有黑色素而被称为暗色真菌。这种真菌具有临床重要性，因为它具有嗜神经性，可引起脑暗色丝孢霉病。
通过从PubMed、Scopus和谷歌学术数据库中筛选描述成人班替枝孢霉真菌感染病例报告的文章，分析有关班替枝孢霉引起脑暗色丝孢霉病发展的现有科学信息，同时考虑对患者症状、临床病史和神经解剖损伤的分析，以及该病的死亡率。
印度和美国是病例报告最多的国家，分别有32例和11例。此外，就神经解剖病变而言，大多数患者患有混合性病变（29%）和额叶病变（22%）。根据患者病情，该病理的死亡率为62%。
得出的结论是，脑暗色丝孢霉病死亡率高，没有标准化治疗方法，而且在大多数情况下，脑部真菌感染是混合性的，会影响大脑的几个不同部位。此外，如果不及时诊断和治疗，可能导致患者死亡。
