在一项大型基于人群的研究中，脾脏体积与血液计数和血脂谱标志物的相关性。

Associations of spleen volume with markers of blood count and lipid profile in a large population-based study.

机构信息

Institute for Community Medicine, University Medicine Greifswald, Germany.

Department of Zoology, University of Malakand, 18800, Pakistan.

出版信息

Ups J Med Sci. 2023 Sep 15;128. doi: 10.48101/ujms.v128.9785. eCollection 2023.

DOI:10.48101/ujms.v128.9785

PMID:37807997

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10552697/

Abstract

BACKGROUND

The aim of our study was to investigate associations of spleen volume with blood count markers and lipid profile in the general population.

MATERIALS & METHODS: Cross-sectional data from 1,106 individuals aged 30-90 years from the population-based Study of Health in Pomerania (SHIP-START-2) were analyzed. Blood count markers included red blood cell (RBC) counts, hemoglobin, platelet count, and white blood cell (WBC) counts. Lipid profile included total-cholesterol, high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) as well as triglycerides. Linear regression models adjusted for age, sex, body height, and weight were used to associate standardized spleen volume with blood counts and lipid profile markers.

RESULTS

Spleen volume was positively associated with RBC ( = 0.05; 95% confidence interval [CI] = 0.03 to 0.08) and hemoglobin (β = 0.05; 95% CI = 0.01 to 0.09) but inversely with platelet count (β = -16.3; 95% CI = -20.5 to -12.1) and WBC (β = -0.25; 95% CI = -0.37 to -0.14). Furthermore, spleen volume showed inverse associations with total cholesterol (β = -0.17; 95% CI = -0.24 to -0.09), HDL-C (β = -0.08; 95% CI = -0.10 to -0.05), and LDL-C (β = -0.12; 95% CI = -0.17 to -0.06). There was no significant association of spleen volume with triglycerides.

CONCLUSION

Our study showed that the spleen volume is associated with markers of the blood count and lipid profile in the general population.

摘要

背景

本研究旨在探讨脾脏体积与全人群血细胞计数标志物和血脂谱的相关性。

材料与方法

对来自基于人群的什未林健康研究（SHIP-START-2）的 1106 名 30-90 岁个体的横断面数据进行分析。血细胞计数标志物包括红细胞（RBC）计数、血红蛋白、血小板计数和白细胞（WBC）计数。血脂谱包括总胆固醇、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯。采用线性回归模型，根据年龄、性别、身高和体重对标准化脾脏体积与血细胞计数和血脂谱标志物进行关联分析。

结果

脾脏体积与 RBC（ = 0.05；95%置信区间 [CI] = 0.03 至 0.08）和血红蛋白（β = 0.05；95% CI = 0.01 至 0.09）呈正相关，与血小板计数（β = -16.3；95% CI = -20.5 至 -12.1）和 WBC（β = -0.25；95% CI = -0.37 至 -0.14）呈负相关。此外，脾脏体积与总胆固醇（β = -0.17；95% CI = -0.24 至 -0.09）、HDL-C（β = -0.08；95% CI = -0.10 至 -0.05）和 LDL-C（β = -0.12；95% CI = -0.17 至 -0.06）呈负相关。脾脏体积与甘油三酯无显著相关性。