2 型糖尿病患者血糖水平与血脂或血脂比值的相关性：一项横断面研究。
The association between blood glucose levels and lipids or lipid ratios in type 2 diabetes patients: A cross-sectional study.
机构信息
Ningxia Regional Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Regional High Incidence Disease, Ningxia Medical University, Yinchuan, China.
Key Laboratory of the Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, China.
出版信息
Front Endocrinol (Lausanne). 2022 Sep 6;13:969080. doi: 10.3389/fendo.2022.969080. eCollection 2022.
BACKGROUND
Lipids and lipid ratios are associated with complications of diabetes mellitus type 2 (T2DM), such as cardiovascular disease, but the relationship between blood glucose levels and lipid or lipid ratios is not fully understood in T2DM patients. This study assesses the association between blood glucose levels and lipid or lipid ratios in a cohort of T2DM patients.
METHODS
A total of 1,747 Chinese T2DM patients from the Ningxia province of China were included in this cross-sectional study. Lipid parameters, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), and fasting blood glucose levels were measured quantitatively using standard methods. Fasting blood glucose was divided into three groups. A multiple mixed-effect linear regression model was conducted to identify a potential association between blood glucose and lipid parameters.
RESULTS
There was a positive association between blood glucose and TG levels (β=0.34, 95% : (0.20, 0.48), 0.01); every 1 mmol/L increase in blood glucose levels resulted in a 0.34 mmol/L increase in TG. Blood glucose levels were also associated with high LDL (β=0.08, 95% : (0.02, 0.14), 0.01), TG/HDL-C (β=0.31, 95% : (0.13, 0.49), 0.01), and LDL-C/HDL-C (β=0.13, 95% : (0.06, 0.20), <0.01) levels. After controlling for demographic variables, health-related behaviors, and physical health variables, a positive association between blood glucose levels and TG (β=0.31, 95% : (0.17, 0.45), 0.01) and LDL-C (β=0.08, 95% : (0.02, 0.13), 0.01) levels and an in increase in TG/HDL-C (β=0.28, 95% : (0.09, 0.46), 0.01) and LDL-C/HDL-C (β=0.11, 95% : (0.04, 0.18), 0.01) ratios was found.
CONCLUSION
A correlation between blood glucose levels and serum lipids or lipid ratios has been established in this study. Blood glucose levels were positively associated with TG and LDL-C levels and elevated TG/HDL-C and LDL-C/HDL-C ratios.
背景
脂质和脂质比值与 2 型糖尿病（T2DM）的并发症有关，如心血管疾病，但 T2DM 患者的血糖水平与脂质或脂质比值之间的关系尚未完全阐明。本研究评估了 T2DM 患者血糖水平与血脂或血脂比值之间的关系。
方法
本横断面研究纳入了来自中国宁夏回族自治区的 1747 名 T2DM 患者。使用标准方法定量测量血脂参数，包括甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）和空腹血糖水平。将空腹血糖分为三组。采用多混合效应线性回归模型来确定血糖与血脂参数之间的潜在关联。
结果
血糖与 TG 水平呈正相关（β=0.34，95%：（0.20，0.48），0.01）；血糖水平每升高 1mmol/L，TG 升高 0.34mmol/L。血糖水平还与高 LDL（β=0.08，95%：（0.02，0.14），0.01）、TG/HDL-C（β=0.31，95%：（0.13，0.49），0.01）和 LDL-C/HDL-C（β=0.13，95%：（0.06，0.20），<0.01）水平相关。在控制人口统计学变量、健康相关行为和身体健康变量后，血糖与 TG（β=0.31，95%：（0.17，0.45），0.01）和 LDL-C（β=0.08，95%：（0.02，0.13），0.01）水平呈正相关，与 TG/HDL-C（β=0.28，95%：（0.09，0.46），0.01）和 LDL-C/HDL-C（β=0.11，95%：（0.04，0.18），0.01）比值升高呈正相关。
结论
本研究建立了血糖水平与血清脂质或脂质比值之间的相关性。血糖水平与 TG 和 LDL-C 水平呈正相关，与 TG/HDL-C 和 LDL-C/HDL-C 比值升高有关。
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