Carey John J, Erjiang E, Wang Tingyan, Yang Lan, Dempsey Mary, Brennan Attracta, Yu Ming, Chan Wing P, Whelan Bryan, Silke Carmel, O'Sullivan Miriam, Rooney Bridie, McPartland Aoife, O'Malley Gráinne
School of Medicine, College of Medicine, Nursing and Health Sciences University of Galway Galway Ireland.
Department of Rheumatology Galway University Hospitals Galway Ireland.
JBMR Plus. 2023 Aug 10;7(10):e10798. doi: 10.1002/jbm4.10798. eCollection 2023 Oct.
Osteoporosis is a common disease that has a significant impact on patients, healthcare systems, and society. World Health Organization (WHO) diagnostic criteria for postmenopausal women were established in 1994 to diagnose low bone mass (osteopenia) and osteoporosis using dual-energy X-ray absorptiometry (DXA)-measured bone mineral density (BMD) to help understand the epidemiology of osteoporosis, and identify those at risk for fracture. These criteria may also apply to men ≥50 years, perimenopausal women, and people of different ethnicity. The DXA Health Informatics Prediction (HIP) project is an established convenience cohort of more than 36,000 patients who had a DXA scan to explore the epidemiology of osteoporosis and its management in the Republic of Ireland where the prevalence of osteoporosis remains unknown. In this article we compare the prevalence of a DXA classification low bone mass (-score < -1.0) and of osteoporosis (T-score ≤ -2.5) among adults aged ≥40 years without major risk factors or fractures, with one or more major risk factors, and with one or more major osteoporotic fractures. A total of 33,344 subjects met our study inclusion criteria, including 28,933 (86.8%) women; 9362 had no fractures or major risk factors, 14,932 had one or more major clinical risk factors, and 9050 had one or more major osteoporotic fractures. The prevalence of low bone mass and osteoporosis increased significantly with age overall. The prevalence of low bone mass and osteoporosis was significantly greater among men and women with major osteoporotic fractures than healthy controls or those with clinical risk factors. Applying our results to the national population census figure of 5,123,536 in 2022 we estimate between 1,039,348 and 1,240,807 men and women aged ≥50 years have low bone mass, whereas between 308,474 and 498,104 have osteoporosis. These data are important for the diagnosis of osteoporosis in clinical practice, and national policy to reduce the illness burden of osteoporosis. © 2023 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
骨质疏松症是一种常见疾病，对患者、医疗系统和社会都有重大影响。世界卫生组织（WHO）于1994年制定了绝经后女性的诊断标准，使用双能X线吸收法（DXA）测量骨矿物质密度（BMD）来诊断低骨量（骨量减少）和骨质疏松症，以帮助了解骨质疏松症的流行病学，并识别骨折风险人群。这些标准也可能适用于50岁及以上的男性、围绝经期女性以及不同种族的人群。DXA健康信息学预测（HIP）项目是一个由超过36,000名接受DXA扫描的患者组成的便利队列，旨在探索爱尔兰共和国骨质疏松症的流行病学及其管理情况，该国骨质疏松症的患病率尚不清楚。在本文中，我们比较了年龄≥40岁、无主要危险因素或骨折、有一个或多个主要危险因素以及有一个或多个严重骨质疏松性骨折的成年人中，DXA分类低骨量（T值＜-1.0）和骨质疏松症（T值≤-2.5）的患病率。共有33,344名受试者符合我们的研究纳入标准，其中包括28,933名（86.8%）女性；9362人无骨折或主要危险因素，14,932人有一个或多个主要临床危险因素，9050人有一个或多个严重骨质疏松性骨折。总体而言，低骨量和骨质疏松症的患病率随年龄显著增加。有严重骨质疏松性骨折的男性和女性中，低骨量和骨质疏松症的患病率显著高于健康对照组或有临床危险因素的人群。将我们的结果应用于2022年全国人口普查数字5,123,536，我们估计年龄≥50岁的男性和女性中，有1,039,348至1,240,807人有低骨量，而有308,474至498,104人患有骨质疏松症。这些数据对于临床实践中骨质疏松症的诊断以及减轻骨质疏松症疾病负担的国家政策具有重要意义。© 2023作者。由Wiley Periodicals LLC代表美国骨与矿物质研究学会出版。
