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丹参酮IIA修复脊髓损伤的可能治疗机制。

Possible mechanisms of treatment for spinal cord injury repair with tanshinone IIA.

作者信息

Jia Zhiwei, Wen Tianlin, Zhang Yuning

机构信息

Department of Orthopaedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.

Class 6 of Year 2021 Clinical Medicine, School of Medicine, Shenzhen University, Shenzhen, Guangdong Province, China.

出版信息

Front Mol Neurosci. 2023 Sep 21;16:1277755. doi: 10.3389/fnmol.2023.1277755. eCollection 2023.

DOI:10.3389/fnmol.2023.1277755
PMID:37808475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10551456/
Abstract

Tanshinone IIA serves as a coenzyme for certain biochemical reactions, exhibiting various pharmacological effects in the treatment of neurological diseases including spinal cord injury (SCI), however, its working mechanism in the treatment of SCI is not clear. Based on previous research, we believe that tanshinone IIA promotes the survival and repair of nerves after spinal cord injury through its pharmacological effects such as anti-inflammatory, antioxidant, and prevention of cellular apoptosis in the spinal cord.

摘要

丹参酮IIA作为某些生化反应的辅酶，在治疗包括脊髓损伤（SCI）在内的神经疾病中表现出多种药理作用，然而，其治疗SCI的作用机制尚不清楚。基于先前的研究，我们认为丹参酮IIA通过其抗炎、抗氧化和预防脊髓细胞凋亡等药理作用促进脊髓损伤后神经的存活和修复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2876/10551456/9cb8ce6c162e/fnmol-16-1277755-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2876/10551456/d3f303d9e0ab/fnmol-16-1277755-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2876/10551456/9cb8ce6c162e/fnmol-16-1277755-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2876/10551456/d3f303d9e0ab/fnmol-16-1277755-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2876/10551456/9cb8ce6c162e/fnmol-16-1277755-g002.jpg

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Possible mechanisms of treatment for spinal cord injury repair with tanshinone IIA.丹参酮IIA修复脊髓损伤的可能治疗机制。
Front Mol Neurosci. 2023 Sep 21;16:1277755. doi: 10.3389/fnmol.2023.1277755. eCollection 2023.
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Sodium tanshinone IIA sulfonate promotes spinal cord injury repair by inhibiting blood spinal cord barrier disruption in vitro and in vivo.丹参酮 IIA 磺酸钠通过抑制血脊髓屏障破坏促进脊髓损伤修复：体内外研究。
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Tanshinone IIA promotes the differentiation of bone marrow mesenchymal stem cells into neuronal-like cells in a spinal cord injury model.丹参酮 IIA 促进骨髓间充质干细胞向脊髓损伤模型中的神经元样细胞分化。
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本文引用的文献

1
Tanshinone IIA Improves Acute Gouty Arthritis in Rats through Regulating Neutrophil Activation and the NLRP3 Inflammasome.丹参酮 IIA 通过调控中性粒细胞活化和 NLRP3 炎性小体改善大鼠急性痛风性关节炎。
Dis Markers. 2022 Dec 19;2022:5851412. doi: 10.1155/2022/5851412. eCollection 2022.
2
Recent Research Progress (2015-2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA.丹参酮IIA药理作用及机制的近期研究进展（2015 - 2021年）与展望
Front Pharmacol. 2021 Nov 8;12:778847. doi: 10.3389/fphar.2021.778847. eCollection 2021.
3
A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging.
一种依赖 sestrin 的 Erk-Jnk-p38 MAPK 激活复合物在衰老过程中抑制免疫。
Nat Immunol. 2017 Mar;18(3):354-363. doi: 10.1038/ni.3665. Epub 2017 Jan 23.
4
Anti-Inflammatory Activity of Tanshinone IIA in LPS-Stimulated RAW264.7 Macrophages via miRNAs and TLR4-NF-κB Pathway.丹参酮IIA通过miRNAs和TLR4-NF-κB通路对脂多糖刺激的RAW264.7巨噬细胞的抗炎活性
Inflammation. 2016 Feb;39(1):375-384. doi: 10.1007/s10753-015-0259-1.
5
Tanshinone IIA attenuates cardiac dysfunction in endotoxin-induced septic mice via inhibition of NADPH oxidase 2-related signaling pathway.丹参酮IIA通过抑制NADPH氧化酶2相关信号通路减轻内毒素诱导的脓毒症小鼠的心脏功能障碍。
Int Immunopharmacol. 2015 Sep;28(1):444-9. doi: 10.1016/j.intimp.2015.07.004. Epub 2015 Jul 17.
6
Tanshinone IIA attenuates the cerebral ischemic injury-induced increase in levels of GFAP and of caspases-3 and -8.丹参酮IIA可减轻脑缺血损伤诱导的胶质纤维酸性蛋白（GFAP）以及半胱天冬酶-3和-8水平的升高。
Neuroscience. 2015 Mar 12;288:105-11. doi: 10.1016/j.neuroscience.2014.12.028. Epub 2015 Jan 6.
7
Sodium tanshinone IIA sulfonate prolongs the survival of skin allografts by inhibiting inflammatory cell infiltration and T cell proliferation.丹参酮IIA磺酸钠通过抑制炎性细胞浸润和T细胞增殖来延长同种异体皮肤移植的存活时间。
Int Immunopharmacol. 2014 Sep;22(1):277-84. doi: 10.1016/j.intimp.2014.07.002. Epub 2014 Jul 14.
8
Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP‑2 and NF‑κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease.丹参酮IIA通过抑制阿尔茨海默病大鼠模型颞叶中的诱导型一氧化氮合酶、基质金属蛋白酶-2和核因子κB p65的转录和翻译来降低患阿尔茨海默病的风险。
Mol Med Rep. 2014 Aug;10(2):689-94. doi: 10.3892/mmr.2014.2254. Epub 2014 May 20.
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[Study on regulation of tanshinone II(A) on GFAP and ATPase and PDI of cerebral ischemia reperfusion injury in rats].[丹参酮Ⅱ（A）对大鼠脑缺血再灌注损伤中胶质纤维酸性蛋白、三磷酸腺苷酶及蛋白二硫键异构酶的调控研究]
Zhong Yao Cai. 2012 Oct;35(10):1628-32.
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Neuroprotective effects of tanshinone IIA and/or tetramethylpyrazine in cerebral ischemic injury in vivo and in vitro.丹参酮 IIA 和/或川芎嗪在体内和体外脑缺血损伤中的神经保护作用。
Brain Res. 2012 Dec 7;1488:81-91. doi: 10.1016/j.brainres.2012.09.034. Epub 2012 Oct 11.