Kardjito T, Beck J S, Grange J M, Stanford J L
Eur J Respir Dis. 1986 Sep;69(3):142-5.
Multiple skin testing with reagents (new tuberculins) prepared from different mycobacterial species places individuals in three categories: those reacting to all reagents (Category 1), those reacting to none (Category 2) and those reacting to some but not all (Category 3). This pattern of reactivity led to the postulate that Category 3 individuals respond only to those antigens that are unique to each individual species, while Category 1 individuals respond to antigens common to all mycobacteria, though a few of the latter may be responding independently to the specific antigens of all the reagents used. The percentage of patients with tuberculosis responding to all of four new tuberculins was much lower than among healthy subjects--a pattern of reactivity observed previously in leprosy. These findings strongly suggest that patients with mycobacterial diseases fail to respond to shared mycobacterial antigens.
使用从不同分枝杆菌物种制备的试剂（新型结核菌素）进行多次皮肤试验，可将个体分为三类：对所有试剂都有反应的个体（第1类）、对所有试剂都无反应的个体（第2类）以及对部分但并非所有试剂有反应的个体（第3类）。这种反应模式导致了一种假设，即第3类个体仅对每个物种特有的那些抗原作出反应，而第1类个体对所有分枝杆菌共有的抗原作出反应，尽管后者中的少数可能是独立地对所用所有试剂的特异性抗原作出反应。结核病患者对四种新型结核菌素全部有反应的百分比远低于健康受试者——这是之前在麻风病中观察到的一种反应模式。这些发现强烈表明，患有分枝杆菌病的患者对分枝杆菌共有抗原无反应。
