Lockwood D N, McManus I C, Stanford J L, Thomas A, Abeyagunawardana D V
School of Pathology, Middlesex Hospital, London, UK.
Eur J Respir Dis. 1987 Nov;71(5):348-55.
Responses to pathogenic and environmental mycobacteria were assessed in 2680 children in India and Sri Lanka using quadruple skin-testing with new tuberculins. Statistical analysis of the results, by fitting a log-linear mixture model, confirmed the presence of three different categories of response: category 2 non-responders (about 55%) did not react to any component of the mycobacteria; category 3 responders (about 40%) were sensitive to the species-specific group iv antigens; and category 1 responders (about 5%) were sensitive to the group i antigens which are common to all mycobacteria. The proportions of the three response categories vary with age and with BCG status. BCG vaccination and increasing age act independently to decrease the proportion of category 2 non-responders and increase the proportion of category 3 individuals. BCG vaccination and increasing age interact to increase the proportion of category 1 responders.
在印度和斯里兰卡，使用新型结核菌素进行四重皮肤试验，对2680名儿童对致病性和环境性分枝杆菌的反应进行了评估。通过拟合对数线性混合模型对结果进行统计分析，证实存在三种不同类型的反应：2类无反应者（约55%）对分枝杆菌的任何成分均无反应；3类反应者（约40%）对种特异性的IV组抗原有反应；1类反应者（约5%）对所有分枝杆菌共有的I组抗原有反应。这三种反应类型的比例随年龄和卡介苗接种状况而变化。卡介苗接种和年龄增长各自独立作用，降低2类无反应者的比例，增加3类个体的比例。卡介苗接种和年龄增长相互作用，增加1类反应者的比例。
