Yoshida Naohisa, Inagaki Yoshikazu, Hasegawa Daisuke, Kobayashi Reo, Tomita Yuri, Hashimoto Hikaru, Hirose Ryohei, Dohi Osamu, Inoue Ken, Morimoto Yasutaka, Inada Yutaka, Murakami Takaaki, Itoh Yoshito
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Department of Gastroenterology, Nishijin Hospital, Kyoto, Japan.
Gastroenterol Res Pract. 2023 Sep 30;2023:6359165. doi: 10.1155/2023/6359165. eCollection 2023.
Oral sulfate solution (OSS) is used for bowel preparation (BP) during colonoscopy. The way of taking this agent can be used a same-day regimen (only on the day of colonoscopy) and split regimen (the day before and on the day of colonoscopy) for receiving it. In this study, we analyzed the efficacy of a same-day regimen of 480 ml OSS for insufficient bowel preparation (BP) with high-concentrated polyethylene glycol (H-PEG).
This multicenter retrospective study was conducted from December 2021 to December 2022 at three related institutions on patients aged ≥ 20 years with a fair or poor Aronchick score of BP with 1 l H-PEG in previous colonoscopy. All patients received a low-residual diet and 10 ml of 0.75% picosulfate sodium a day before the colonoscopy and 480 ml of OSS and ≥1 l of water 3 hours before the colonoscopy. We analyzed the rate of improvement with OSS compared to H-PEG and other efficacies, and adverse events (AE).
We evaluated 125 cases (77 males) with an average age of 72.1 ± 8.8 years. The completion rate of 480 ml of OSS was 97.6% (122/125). The improvement rate of BP showing good or excellent score with OSS was 70.4% (88/125). Compared OSS with previous H-PEG, the insertion time (min) was 7.0 ± 4.8 vs. 8.1 ± 6.0 ( = 0.01), and the adenoma detection rates were 67.2% vs. 63.2% ( = 0.05). The cleansing time (min) was 131 ± 46 vs. 165 ± 53 ( < 0.01). The rate of AE with OSS was 10.4% (13/125). There were no significant differences about AE in age and gender. The tolerance of OSS compared with H-PEG (good/similar/bad) was 72.0%/24.8%/3.2% (amounts), 26.4%/39.2%/34.4% (taste), and 76.8%/10.4%/12.8% (overall preference), respectively.
The same-day regimen of 480 ml OSS effectively improved the insufficient BP of 1 l H-PEG.
口服硫酸盐溶液（OSS）用于结肠镜检查期间的肠道准备（BP）。服用该药物的方式可采用当日方案（仅在结肠镜检查当天）和分阶段方案（结肠镜检查前一天和当天）。在本研究中，我们分析了480毫升OSS当日方案对高浓度聚乙二醇（H-PEG）肠道准备不足（BP）的疗效。
本多中心回顾性研究于2021年12月至2022年12月在三个相关机构对年龄≥20岁、之前结肠镜检查中BP的Aronchick评分中等或较差且使用1升H-PEG的患者进行。所有患者在结肠镜检查前一天接受低残留饮食和10毫升0.75%的匹可硫酸钠，在结肠镜检查前3小时接受480毫升OSS和≥1升水。我们分析了与H-PEG相比OSS的改善率及其他疗效，以及不良事件（AE）。
我们评估了125例患者（77例男性），平均年龄为72.1±8.8岁。480毫升OSS的完成率为97.6%（122/125）。OSS显示BP评分良好或优秀的改善率为70.4%（88/125）。将OSS与之前的H-PEG相比，插入时间（分钟）为7.0±4.8 vs. 8.1±6.0（P = 0.01），腺瘤检出率分别为67.2% vs. 63.2%（P = 0.05）。清洁时间（分钟）为131±46 vs. 165±53（P < 0.01）。OSS的AE发生率为10.4%（13/125）。年龄和性别在AE方面无显著差异。与H-PEG相比，OSS的耐受性（好/相似/差）在量方面分别为72.0%/24.8%/3.2%，在味道方面分别为26.4%/39.2%/34.4%，在总体偏好方面分别为76.8%/10.4%/12.8%。
480毫升OSS当日方案有效改善了1升H-PEG肠道准备不足的情况。
