Yoshida Naohisa, Inagaki Yoshikazu, Fukumoto Kohei, Yoriki Hiroyuki, Inada Yutaka, Murakami Takaaki, Tomita Yuri, Hashimoto Hikaru, Sugino Satoshi, Hirose Ryohei, Dohi Osamu, Inoue Ken, Itoh Yoshito
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Department of Gastroenterology, Nishijin Hospital, Kyoto, Japan.
Gastroenterol Res Pract. 2020 Nov 24;2020:8886073. doi: 10.1155/2020/8886073. eCollection 2020.
This multicenter retrospective study was conducted from September 2019 to September 2020 at 5 related institutions among patients ≥ 20 years old diagnosed with chronic constipation whose previous colonoscopic BP had had a fair or poor Aronchick score. Two or four sachets of PEG+E (13.7 or 27.4 g/day) were prescribed for 1 week before colonoscopy. We analyzed the rate of improvement in BP, effect-related factors, spontaneous bowel movements (SBMs), stool consistency, improvement of constipation symptoms, and adverse events.
We evaluated 106 cases (56 males) with an average age of 69.5 ± 9.4 years old (≤74 years old: 68 cases, ≥75 years old: 38 cases). The improvement rate of BP was 72.6%, and the insertion time and pain score also improved. A performance status of 1 or 2 was associated with poor BP. SBMs (times/week) increased from 4.0 ± 1.9 to 6.1 ± 2.6 ( < 0.001). The overall improvement rates of SBMs, stool consistency, symptoms of constipation, and rate of adverse events were 58.5%, 90.6%, 59.4%, and 6.6%, respectively, showing no significant differences with regard to age or gender.
Short-duration PEG+E was effective for improving poor BP and chronic constipation.
本多中心回顾性研究于2019年9月至2020年9月在5家相关机构对年龄≥20岁、被诊断为慢性便秘且既往结肠镜检查肠道准备（BP）的阿隆奇克评分中等或较差的患者进行。在结肠镜检查前1周，给予患者两包或四包聚乙二醇+电解质（PEG+E，13.7或27.4克/天）。我们分析了肠道准备的改善率、疗效相关因素、自主排便（SBM）、大便性状、便秘症状的改善情况以及不良事件。
我们评估了106例患者（56例男性），平均年龄为69.5±9.4岁（≤74岁：68例，≥75岁：38例）。肠道准备的改善率为72.6%，插入时间和疼痛评分也有所改善。身体状况评分为1或2与肠道准备不佳相关。自主排便次数（每周）从4.0±1.9增加到6.1±2.6（<0.001）。自主排便、大便性状、便秘症状的总体改善率以及不良事件发生率分别为58.5%、90.6%、59.4%和6.6%，在年龄或性别方面无显著差异。
短期使用PEG+E对改善肠道准备不佳和慢性便秘有效。
