Millennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
Front Public Health. 2023 Sep 22;11:1253762. doi: 10.3389/fpubh.2023.1253762. eCollection 2023.
To assess the effectiveness of four doses of the vaccine against SARS-CoV-2 in the general population and the impact of this on the severity of the disease by age group.
By using data from the health authority public data base, we build statistical models using R and the GAMLSS library to explain the behavior of new SARS-CoV-2 infections, active COVID-19 cases, ICU bed requirement total and by age group, and deaths at the national level.
The four doses of vaccine and at least the interaction between the first and second doses were important explanatory factors for the protective effect against COVID-19. The for new cases per day was 0.5644 and for occupied ICU beds the is 0.9487. For occupied ICU beds for >70 years is 0.9195 and with the interaction between 4 doses as the main factor.
Although the increase in the number of vaccine doses did not adequately explain the decrease in the number of COVID-19 cases, it explained the decrease in ICU admissions and deaths nationwide and by age group.
评估普通人群中接种四剂 SARS-CoV-2 疫苗的效果，以及按年龄组评估这对疾病严重程度的影响。
我们利用卫生当局公共数据库中的数据，使用 R 和 GAMLSS 库构建统计模型，以解释新的 SARS-CoV-2 感染、活跃的 COVID-19 病例、总 ICU 床位需求和按年龄组划分的 ICU 床位需求以及全国范围内的死亡人数的行为。
四剂疫苗，以及至少第一剂和第二剂之间的相互作用，是对 COVID-19 具有保护作用的重要解释因素。新发病例的日增长率为 0.5644，占用 ICU 床位的增长率为 0.9487。对于>70 岁的 ICU 床位，增长率为 0.9195，主要因素是四剂疫苗之间的相互作用。
尽管疫苗接种剂量的增加并不能充分解释 COVID-19 病例的减少，但它解释了全国范围内以及按年龄组划分的 ICU 入院和死亡人数的减少。
