DSP-4治疗可加速点燃效应。

DSP-4 treatment accelerates kindling.

作者信息

Carre G, Harley C

出版信息

Exp Neurol. 1986 Dec;94(3):812-6. doi: 10.1016/0014-4886(86)90262-1.

Abstract

Norepinephrine depletion of the central nervous system by peripheral N-(2-chloroethyl)-N-ethyl bromobenzylamine administration accelerates the development of seizures kindled by repeated stimulation of the amygdala. These data, in conjunction with previous 6-hydroxydopamine data, demonstrate the robustness of this phenomenon and emphasize the importance of noradrenergic innervation originating from the locus ceruleus in the suppression of seizure development.

摘要

通过外周给予N-(2-氯乙基)-N-乙基溴苄胺使中枢神经系统去甲肾上腺素耗竭，会加速因反复刺激杏仁核而引发的癫痫发作的发展。这些数据与之前关于6-羟基多巴胺的数据一起，证明了这一现象的顽固性，并强调了源自蓝斑的去甲肾上腺素能神经支配在抑制癫痫发作发展中的重要性。