Depletion of noradrenaline fails to affect kindled seizures.

Convulsive seizures were kindled in rats by repeated stimulation of the amygdala, and the subjects then received intracerebral injections of 6-hydroxydopamine into the dorsal noradrenergic bundle. Although this treatment severely depleted noradrenaline, there was no effect on the intensity or duration of seizures, suggesting that noradrenaline does not regulate kindled seizures when they have developed.