Yong L C, Bleasel A F
Exp Pathol. 1986;30(2):97-107. doi: 10.1016/s0232-1513(86)80067-6.
The structural changes in kidneys of diabetic rats induced by streptozotocin were compared with those of age-matched control animals. Degenerative changes were found in the distal tubules of diabetic rats as early as 2 weeks following the onset of diabetes and by one month the entire distal tubule was severely affected. Fibrinoid lesions were also found in diabetic rats after 4 weeks of the disease and became more frequent subsequently. IgG, albumin but not C3 were also found in the glomerular basement membrane of diabetic rats. Diabetic glomerulosclerosis was present only after several weeks, affected glomeruli showed diffuse mesangial sclerosis and only occasionally nodular sclerosis. Diabetic animals developed renal cortical adenomas and mesenchymal tumours after several months.
将链脲佐菌素诱导的糖尿病大鼠肾脏结构变化与年龄匹配的对照动物进行比较。早在糖尿病发病后2周，糖尿病大鼠的远端小管就出现了退行性变化，到1个月时，整个远端小管受到严重影响。患病4周后，糖尿病大鼠还出现了纤维蛋白样病变，且随后变得更加频繁。在糖尿病大鼠的肾小球基底膜中也发现了IgG、白蛋白，但未发现C3。糖尿病肾小球硬化仅在数周后出现，受影响的肾小球表现为弥漫性系膜硬化，仅偶尔出现结节性硬化。几个月后，糖尿病动物出现了肾皮质腺瘤和间充质肿瘤。
