Qian Weiwei, He Chengtong, Ren Yan, Xian Xiaoyan, Jiang Zhen, Xu Shuyun
Department of Emergency Medicine, Laboratory of Emergency Medicine, West China Hospital, And Disaster Medical Center, Sichuan University, Chengdu, 610041, Sichuan, China.
Department of Emergency, Shangjinnanfu Hospital, West China Hospital, Sichuan University, Chengdu, 610044, Sichuan, China.
Heliyon. 2023 Sep 5;9(9):e19811. doi: 10.1016/j.heliyon.2023.e19811. eCollection 2023 Sep.
Bromadiolone, as a second-generation coumarin anticoagulant rodenticide, may accidently cause harm to humans and non-target animals when overused or misused due to its high toxicity and long-lasting effects. In some severe cases such as the presence of active bleeding, treatment should involve the administration of hemoperfusion therapy. Nafamostat mesylate is a synthesized protease inhibitor that inhibits most factors in the coagulation process, preventing clotting and ensuring smooth blood flow during the procedure. Nafamostat mesylate helps maintain the efficacy and safety of hemoperfusion treatment. Despite its wide application in Japan, the clinical practice and research of nafamostat mesylate are limited in China, especially for patients undergoing maintenance hemodialysis. This paper reports two cases of bromadiolone poisoning and describes the treatment procedure and therapeutic effect of anticoagulation in hemoperfusion therapy with nafamostat mesylate.
溴敌隆作为第二代香豆素类抗凝血灭鼠剂，由于其高毒性和长效性，过度使用或滥用时可能意外对人类和非靶标动物造成伤害。在一些严重病例中，如出现活动性出血，治疗应包括血液灌流疗法。甲磺酸萘莫司他是一种合成的蛋白酶抑制剂，可抑制凝血过程中的大多数因子，防止凝血并确保手术过程中血液顺畅流动。甲磺酸萘莫司他有助于维持血液灌流治疗的疗效和安全性。尽管甲磺酸萘莫司他在日本广泛应用，但在中国其临床实践和研究有限，尤其是对于接受维持性血液透析的患者。本文报告了两例溴敌隆中毒病例，并描述了甲磺酸萘莫司他在血液灌流治疗中抗凝的治疗过程和治疗效果。
