Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Nutrients. 2023 Jul 19;15(14):3203. doi: 10.3390/nu15143203.
Alzheimer's disease (AD) is a globally prevalent neurodegenerative disorder, the underlying causes and mechanisms of which remain elusive. The emerging interest in the potential connection between gut microbes and AD prompted our study to investigate this field through bibliometric analysis. To examine research trends over the past decade, we collected relevant data using search terms associated with gut microbiota and AD from the Web of Science Core Collection. Our analysis involved various tools, including R (version 4.2.2), VOSviewer (version 1.6.18), CiteSpace software (version 6.2.R1), and an online bibliometric platform. Our findings identified a total of 1170 articles published between 2012 and 2022, indicating a consistent growth of research interest in this area. Notably, China significantly contributed with 40.7% (374) of the publications, signifying its prominent role in this field. Among the journals, the Journal of Alzheimer's Disease published the highest number of articles (57; 4.9%). In terms of author influence, Wang Y, with an H-index of 13, emerged as the most influential author. Additionally, Shanghai Jiaotong University was the most productive institution, accounting for 66 articles (5.6%). Through keyword analysis, we grouped high-frequency keywords into six clusters: gut microbiota, AD, neuroinflammation, gut-brain axis, oxidative stress, and chain fatty acids. Chain fatty acids, oxidative stress, and the gut-brain axis emerged as dominant research topics in the past five years. Recent studies have specifically focused on "nlrp3 inflammasome" and "clearance" (2020-2022), indicating shifting research interests within this field. This bibliometric analysis aims to provide insights into the evolving landscape of research on the gut microbiota and AD. Our results identify key research trends and themes while highlighting potential research gaps. The findings offer valuable perspectives for future investigations, advancing our understanding of AD and exploring potential therapeutic strategies.
阿尔茨海默病（AD）是一种全球流行的神经退行性疾病，其根本原因和机制仍不清楚。人们对肠道微生物群与 AD 之间潜在联系的兴趣日益浓厚，促使我们通过文献计量学分析来研究这一领域。为了研究过去十年的研究趋势，我们使用与肠道微生物群和 AD 相关的搜索词从 Web of Science 核心合集收集了相关数据。我们的分析涉及各种工具，包括 R（版本 4.2.2）、VOSviewer（版本 1.6.18）、CiteSpace 软件（版本 6.2.R1）和在线文献计量学平台。我们的研究结果确定了 2012 年至 2022 年间发表的总共 1170 篇文章，表明该领域的研究兴趣持续增长。值得注意的是，中国以 40.7%（374 篇）的出版物显著贡献，表明其在该领域的突出作用。在期刊中，《阿尔茨海默病杂志》发表的文章最多（57 篇；4.9%）。在作者影响力方面，H-index 为 13 的 Wang Y 是最具影响力的作者。此外，上海交通大学是最具生产力的机构，发表了 66 篇文章（5.6%）。通过关键词分析，我们将高频关键词分为六个聚类：肠道微生物群、AD、神经炎症、肠脑轴、氧化应激和链脂肪酸。过去五年，链脂肪酸、氧化应激和肠脑轴成为主要研究课题。最近的研究特别关注“nlrp3 炎性小体”和“清除”（2020-2022 年），表明该领域的研究兴趣正在发生变化。这项文献计量学分析旨在提供对肠道微生物群和 AD 研究不断发展的景观的见解。我们的研究结果确定了关键的研究趋势和主题，同时突出了潜在的研究差距。研究结果为未来的研究提供了有价值的视角，加深了我们对 AD 的理解，并探索了潜在的治疗策略。
