Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, UK.
Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, UK.
J Nutr Sci. 2021 Sep 13;10:e73. doi: 10.1017/jns.2021.68. eCollection 2021.
Montmorency tart cherries (MC) have been found to modulate indices of vascular function with interventions of varying duration. The objective of this preliminary study was to identify the chronic effects of MC supplementation on vascular function and the potential for urinary metabolomics to provide mechanistic evidence. We performed a placebo-controlled, double-blind, randomised study on 23 healthy individuals (18M, 7F) that consumed 30 ml MC or a placebo twice daily for 28 days. Whole body measures of vascular function and spot urine collections were taken at baseline and after supplementation. There were no significant changes to vascular function including blood pressure and arterial stiffness. Urinary metabolite profiling highlighted significant changes ( < 0⋅001) with putative discriminatory metabolites related to tryptophan and histidine metabolism. Overall, MC supplementation for 28 days does not improve indices of vascular function but changes to the urinary metabolome could be suggestive of potential mechanisms.
蒙莫朗西酸樱桃（MC）已被发现可通过不同持续时间的干预来调节血管功能指标。本初步研究的目的是确定 MC 补充剂对血管功能的慢性影响，以及尿液代谢组学提供机制证据的潜力。我们对 23 名健康个体（18 名男性，7 名女性）进行了一项安慰剂对照、双盲、随机研究，这些个体每天两次服用 30 毫升 MC 或安慰剂，持续 28 天。在基线和补充后进行了全身血管功能测量和点尿采集。血管功能（包括血压和动脉僵硬）没有显著变化。尿代谢物分析突出显示了显著变化（<0.001），与色氨酸和组氨酸代谢相关的潜在鉴别代谢物。总体而言，MC 补充 28 天不会改善血管功能指标，但尿液代谢组的变化可能提示潜在机制。
