Valsamidou Evdokia, Amerikanou Charalampia, Tzavara Chara, Skarpas George, Mariolis-Sapsakos Theodoros D, Zoumpoulakis Panagiotis, Kaliora Andriana C
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 El Venizelou Ave. 17677, Athens, Greece.
Qualia Pharma, 2 Kalavriton, 14564, Kifissia, Athens, Greece.
Heliyon. 2023 Sep 14;9(9):e20143. doi: 10.1016/j.heliyon.2023.e20143. eCollection 2023 Sep.
Osteoarthritis (OA) is a degenerative disease of the joints that affects greatly the elderly population and the health care systems and is on the increase due to aging and obesity. Interventions aim at palliative care and pharmaceutical therapies entail serious adverse events. Whereas polyphenols constitute a promising holistic approach in the arsenal of physicians, trials investigating biomarkers and questionnaires are scarce. As such, a randomized controlled trial (RCT) was conducted to evaluate the potency of a standardized polyphenolic supplement in the management of systemic inflammation, oxidative stress, pain and general quality of life (QoL) in patients with osteoarthritis. Sixty subjects were randomized to receive either a polyphenol supplement (curcuma phospholipid, rosemary extract, resveratrol, ascorbic acid), or an active comparator (ascorbic acid) twice, daily for 12 weeks. The group that received the polyphenols exhibited significantly lower symptoms of pain and improved physical function and QoL as it was depicted by validated questionnaires, compared to the control group. Furthermore, post intervention, inflammation was restrained in the polyphenol group. Since systemic inflammation promotes local inflammation, the decrease of pain herein might be attributed to the attenuation of systemic inflammation by the polyphenols.
骨关节炎（OA）是一种关节退行性疾病，对老年人群体和医疗保健系统影响极大，且由于老龄化和肥胖问题呈上升趋势。干预措施旨在缓解疼痛，而药物治疗会带来严重的不良事件。尽管多酚在医生的治疗手段中是一种很有前景的整体治疗方法，但研究生物标志物和调查问卷的试验却很少。因此，开展了一项随机对照试验（RCT），以评估标准化多酚补充剂对骨关节炎患者全身炎症、氧化应激、疼痛和总体生活质量（QoL）的治疗效果。60名受试者被随机分为两组，一组每日两次服用多酚补充剂（姜黄磷脂、迷迭香提取物、白藜芦醇、抗坏血酸），另一组每日两次服用活性对照剂（抗坏血酸），为期12周。与对照组相比，服用多酚的组在经过验证的问卷中显示出疼痛症状显著减轻，身体功能和生活质量得到改善。此外，干预后，多酚组的炎症得到抑制。由于全身炎症会促进局部炎症，此处疼痛的减轻可能归因于多酚对全身炎症的减轻作用。
