Joshi S G, Zamah N M, Raikar R S, Buttram V C, Henriques E S, Gordon M
Fertil Steril. 1986 Dec;46(6):1077-82.
We examined the proteins in serum and peritoneal fluid of women with endometriosis (and of healthy controls) for evidence of an autoimmune response that might account for their impaired fertility. No antibodies against endometrial glycoproteins or against "progestin dependent endometrial protein" (PEP) were found in any serum or peritoneal fluid sample. Levels of PEP were not different in serum from women with moderate to severe endometriosis (n = 6), with mild endometriosis (n = 21), or from disease-free cycling controls (n = 19). PEP levels in peritoneal fluid from mild endometriosis and from controls did not differ but were elevated ten times in fluid obtained in the secretory phase from women with moderate to severe disease. This suggests that PEP levels in peritoneal fluid reflect the extent of ectopic endometrial growth. The salient finding was a heretofore undescribed protein (mol wt 70,000) in secretory phase peritoneal fluid samples (18/20) and its absence during the proliferative phase (0/35).
我们检测了子宫内膜异位症患者（以及健康对照者）血清和腹水中的蛋白质，以寻找可能导致其生育能力受损的自身免疫反应证据。在任何血清或腹水样本中均未发现针对子宫内膜糖蛋白或“孕激素依赖性子宫内膜蛋白”（PEP）的抗体。中度至重度子宫内膜异位症患者（n = 6）、轻度子宫内膜异位症患者（n = 21）或无疾病的月经周期对照者（n = 19）血清中的PEP水平并无差异。轻度子宫内膜异位症患者腹水中的PEP水平与对照者并无差异，但在中度至重度疾病患者分泌期获得的腹水中，PEP水平升高了10倍。这表明腹水中的PEP水平反映了异位子宫内膜生长的程度。一个显著的发现是，在分泌期腹水样本中（18/20）发现了一种此前未描述过的蛋白质（分子量70,000），而在增殖期样本中未发现（0/35）。
