肌肉减少症是化脓性肝脓肿患者不良预后的重要决定因素。

Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess.

作者信息

Liu Li, Liu Shaohua, Hao Meng, Hu Song, Yu Tian, Yang Yunkai, Liu Zhelong

机构信息

Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei, China.

出版信息

PeerJ. 2023 Oct 4;11:e16055. doi: 10.7717/peerj.16055. eCollection 2023.

DOI:10.7717/peerj.16055

PMID:37810784

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10559880/

Abstract

BACKGROUND

Low muscle mass/sarcopenia has been associated with poor prognosis in many diseases, but its clinical significance in pyogenic liver abscess (PLA) remains unclear. The purpose of this study is to investigate the relationship between muscle mass and prognosis of patients with PLA.

METHODS

A total of 154 adult patients with PLA hospitalized at Tongji Hospital (Wuhan, Hubei, China) between October 2011 and June 2021 were included in this retrospective analysis. Muscle-fat related indicators were measured by computed tomography (CT) images at the third lumbar vertebra (L3) level. The data of patients between the sarcopenia group and non-sarcopenia group were compared. Multivariate logistic regression and receiver operating characteristic (ROC) curve analyses were performed.

RESULTS

The skeletal muscle index (SMI) was independently associated with adverse outcomes (95% CI [0.649-0.954], = 0.015) of PLA in multivariate logistic regression analysis. This conclusion held true in sex-specific subgroup analysis. ROC analysis indicated that SMI may predict adverse outcomes in both male (area under the ROC curve [AUC], 0.718; cut-off, 52.59; < 0.001) and female (AUC, 0.714; cut-off, 38.39; = 0.017) patient populations.

CONCLUSIONS

Sarcopenia serves as an independent risk factor for poor prognosis in PLA and patients with sarcopenia may be more prone to adverse outcomes.

摘要

背景

低肌肉量/肌肉减少症与多种疾病的不良预后相关，但其在肝脓肿（PLA）中的临床意义尚不清楚。本研究旨在探讨PLA患者肌肉量与预后之间的关系。

方法

本回顾性分析纳入了2011年10月至2021年6月期间在华中科技大学同济医学院附属同济医院（中国湖北武汉）住院的154例成年PLA患者。通过第三腰椎（L3）水平的计算机断层扫描（CT）图像测量肌肉脂肪相关指标。比较肌肉减少症组和非肌肉减少症组患者的数据。进行多因素逻辑回归和受试者工作特征（ROC）曲线分析。

结果

在多因素逻辑回归分析中，骨骼肌指数（SMI）与PLA的不良结局独立相关（95%CI[0.649 - 0.954]，P = 0.015）。这一结论在性别特异性亚组分析中也成立。ROC分析表明，SMI可预测男性（ROC曲线下面积[AUC]，0.718；截断值，52.59；P < 0.001）和女性（AUC，0.714；截断值，38.39；P = 0.017）患者群体的不良结局。