Sun Yihan, Jiang Genyi, Wu Qianhua, Ye Lei, Li Bilan
Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
School of Medicine, Tongji University, Shanghai, China.
Front Oncol. 2023 Sep 22;13:1213347. doi: 10.3389/fonc.2023.1213347. eCollection 2023.
Tumor-associated macrophages (TAMs) are the main immune cells in the tumor microenvironment (TME) of endometrial cancer (EC). TAMs recruitment and polarization in EC is regulated by the TME of EC, culminating in a predominantly M2-like macrophage infiltration. TAMs promote lymphatic angiogenesis through cytokine secretion, aid immune escape of EC cells by synergizing with other immune cells, and contribute to the development of EC through secretion of exosomes so as to promoting EC development. EC is a hormone- and metabolism-dependent cancer, and TAMs promote EC through interactions on estrogen receptor (ER) and metabolic factors such as the metabolism of glucose, lipids, and amino acids. In addition, we have explored the predictive significance of some TAM-related indicators for EC prognosis, and TAMs show remarkable promise as a target for EC immunotherapy.
肿瘤相关巨噬细胞（TAMs）是子宫内膜癌（EC）肿瘤微环境（TME）中的主要免疫细胞。EC中TAMs的募集和极化受EC的TME调节，最终导致主要为M2样巨噬细胞浸润。TAMs通过细胞因子分泌促进淋巴管生成，通过与其他免疫细胞协同作用帮助EC细胞免疫逃逸，并通过分泌外泌体促进EC发展。EC是一种激素和代谢依赖性癌症，TAMs通过与雌激素受体（ER）以及葡萄糖、脂质和氨基酸代谢等代谢因子相互作用促进EC发展。此外，我们还探讨了一些TAM相关指标对EC预后的预测意义，TAMs作为EC免疫治疗的靶点显示出显著前景。
