C-反应蛋白在子宫内膜癌患者中的预后作用：一项荟萃分析。
Prognostic role of C-reactive protein in patients with endometrial cancer: a meta-analysis.
机构信息
Department of Gynecology & Obstetrics, Huzhou Maternity & Child Health Care Hospital, Huzhou, 313000, Zhejiang, China.
出版信息
Biomark Med. 2024;18(6):279-289. doi: 10.2217/bmm-2023-0810. Epub 2024 Apr 19.
Abstract
The present meta-analysis aimed to explore the association between C-reactive protein (CRP) levels and the prognosis of patients with endometrial cancer (EC). The effect of CRP level on predicting overall survival (OS) and disease-free survival (DFS) in patients with EC was evaluated according to pooled hazard ratios (HRs) and corresponding 95% CIs. High CRP levels were not significantly correlated with OS (HR: 1.32 [95% CI: 0.99-1.77]; p = 0.060) or DFS (HR: 1.05 [95% CI: 0.88-1.25]; p = 0.597) in patients with EC. CRP levels did not significantly predict OS or DFS in patients with EC. However, according to subgroup analyses, higher CRP levels were significantly associated with poor OS in Asian patients with EC.
摘要
本荟萃分析旨在探讨 C 反应蛋白（CRP）水平与子宫内膜癌（EC）患者预后的关系。根据合并的风险比（HR）和相应的 95%置信区间（CI），评估 CRP 水平对预测 EC 患者总生存期（OS）和无病生存期（DFS）的影响。高 CRP 水平与 OS（HR：1.32 [95% CI：0.99-1.77]；p=0.060）或 DFS（HR：1.05 [95% CI：0.88-1.25]；p=0.597）均无显著相关性。在 EC 患者中，CRP 水平不能显著预测 OS 或 DFS。然而，根据亚组分析，高 CRP 水平与亚洲 EC 患者的不良 OS 显著相关。
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