Liang Tiantian, Feng Zongqi, Zhang Xiao, Li Tianfang, Yang Tingyu, Yu Lan
Graduate School, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Clinical Medical Research Center, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia, China.
Front Bioeng Biotechnol. 2023 Sep 21;11:1266888. doi: 10.3389/fbioe.2023.1266888. eCollection 2023.
Cancer has keeping the main threat to the health of human being. Its overall survival rate has shown rare substantial progress in spite of the improving diagnostic and treatment techniques for cancer in recent years. Indeed, such classic strategies for malignant tumor as surgery, radiation and chemotherapy have been developed and bring more hope to the patients, but still been accompanied by certain limitations, which include the challenge of managing large wound sizes, systemic toxic side effects, and harmful to the healthy tissues caused by imprecise alignment with tumors in radiotherapy. Furthermore, immunotherapy exhibits a limited therapeutic effect in advanced tumors which is reported only up to 25%-30%. The combination of nanomaterials and cancer treatment offers new hope for cancer patients, demonstrating strong potential in the field of medical research. Among the extensively utilized nanomaterials, calcium carbonate nanomaterials (CCNM) exhibit a broad spectrum of biomedical applications due to their abundant availability, cost-effectiveness, and exceptional safety profile. CCNM have the potential to elevate intracellular Ca levels in tumor cells, trigger the mitochondrial damage and ultimately lead to tumor cell death. Moreover, compared with other types of nanomaterials, CCNM exhibit remarkable advantages as delivery systems owing to their high loading capacity, biocompatibility and biodegradability. The purpose of this review is to provide an overview of CCNM synthesis, focusing on summarizing its diverse roles in cancer treatment and the benefits and challenges associated with CCNM in cancer therapy. Hoping to present the significance of CCNM as for the clinical application, and summarize information for the design of CCNM and other types of nanomaterials in the future.
癌症一直是人类健康的主要威胁。尽管近年来癌症的诊断和治疗技术有所改进，但其总体生存率仍鲜有显著进展。事实上，诸如手术、放疗和化疗等经典的恶性肿瘤治疗策略已经得到发展，并给患者带来了更多希望，但仍存在一定局限性，包括处理大伤口尺寸的挑战、全身毒性副作用，以及放疗中与肿瘤精准对准不佳对健康组织造成的损害。此外，免疫疗法在晚期肿瘤中的治疗效果有限，据报道仅为25%-30%。纳米材料与癌症治疗的结合为癌症患者带来了新希望，在医学研究领域展现出强大潜力。在广泛使用的纳米材料中，碳酸钙纳米材料（CCNM）因其丰富的可得性、成本效益和出色的安全性，展现出广泛的生物医学应用。CCNM有潜力提高肿瘤细胞内的钙水平，引发线粒体损伤并最终导致肿瘤细胞死亡。此外，与其他类型的纳米材料相比，CCNM作为递送系统具有显著优势，因其具有高负载能力、生物相容性和可生物降解性。本综述的目的是概述CCNM的合成，重点总结其在癌症治疗中的多种作用以及CCNM在癌症治疗中相关的益处和挑战。希望阐述CCNM在临床应用中的意义，并为未来CCNM及其他类型纳米材料的设计总结相关信息。
