Department of Gastrointestinal Surgery, The 2Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Huan Kui Academy, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Front Immunol. 2024 Jul 22;15:1432633. doi: 10.3389/fimmu.2024.1432633. eCollection 2024.
Mitochondrial damage has a particular impact on the immune system and tumor microenvironment, which can trigger cell stress, an inflammatory response, and disrupt immune cell function, thus all of which can accelerate the progression of the tumor. Therefore, it is of essence to comprehend how the immune system function and the tumor microenvironment interact with mitochondrial dysfunction for cancer treatment. Preserving the integrity of mitochondria or regulating the function of immune cells, such as macrophages, may enhance the efficacy of cancer therapy. Future research should concentrate on the interactions among mitochondria, the immune system, and the tumor microenvironment to identify new therapeutic strategies.
线粒体损伤对免疫系统和肿瘤微环境有特殊影响，可引发细胞应激、炎症反应，并破坏免疫细胞功能，从而加速肿瘤进展。因此，理解免疫系统功能和肿瘤微环境如何与线粒体功能障碍相互作用对于癌症治疗至关重要。保持线粒体的完整性或调节免疫细胞（如巨噬细胞）的功能，可能会提高癌症治疗的效果。未来的研究应集中于线粒体、免疫系统和肿瘤微环境之间的相互作用，以确定新的治疗策略。
