Oketola Banke, Akinrolie Olayinka, Webber Sandra, Askin Nicole, Rabbani Rasheda, Abou-Setta Ahmed M, Singh Harminder
Applied Health Sciences Program, Faculty of Graduate Studies, University of Manitoba, Winnipeg, Canada.
Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
J Can Assoc Gastroenterol. 2023 Aug 10;6(5):162-171. doi: 10.1093/jcag/gwad021. eCollection 2023 Oct.
Physical activity (PA) may benefit people with inflammatory bowel diseases (IBD) by improving immunological response, musculoskeletal function, and psychological health.
We distilled available evidence on the efficacy and safety of PA to improve health-related quality of life (HRQoL) and relieve persistent symptoms of fatigue, joint pain, abdominal pain, stress, anxiety, and depression in individuals with quiescent/mild IBD.
We searched for trials in eight databases and trial registries. Trials using PA as an adjunct therapy in the management of adults (≥18 years) with quiescent or mild IBD, published in English between 2011 and 2023 were identified. Summary effect estimates were expressed as standardized mean difference (SMD) or mean difference (MD) with 95% confidence interval (CI) using random-effects model.
From the 10,862 citations retrieved, we included seven randomized controlled trials (RCTs) and one non-RCT. There was no evidence of benefit of PA on HRQoL (SMD 0.34, 95%CI -0.08 to 0.77; I 57%); high heterogeneity was noted among included trials. PA was found to be efficacious in reducing anxiety (SMD -0.35, 95%CI -0.65 to -0.05; I 0%). There was insufficient evidence to make conclusions regarding changes in fatigue, joint pain, abdominal pain, stress, and depression. All trials deemed physical activity safe.
PA contributes to reducing anxiety in quiescent/mild IBD. There is marked heterogeneity in methodology among trials investigating PA in adults with quiescent/mild IBD. This review highlights the need for consistent definitions of PA types and intensities in this field of research.
体育活动（PA）可能通过改善免疫反应、肌肉骨骼功能和心理健康，使炎症性肠病（IBD）患者受益。
我们汇总了关于PA改善静止期/轻度IBD患者健康相关生活质量（HRQoL）以及缓解疲劳、关节疼痛、腹痛、压力、焦虑和抑郁等持续症状的有效性和安全性的现有证据。
我们在八个数据库和试验注册库中检索试验。确定了2011年至2023年间以英文发表的、将PA用作辅助治疗手段来管理静止期或轻度IBD成年患者（≥18岁）的试验。采用随机效应模型，汇总效应估计值以标准化均数差（SMD）或均数差（MD）及95%置信区间（CI）表示。
在检索到的10862条文献中，我们纳入了七项随机对照试验（RCT）和一项非RCT。没有证据表明PA对HRQoL有有益影响（SMD 0.34，95%CI -0.08至0.77；I² 57%）；纳入的试验之间存在高度异质性。发现PA在减轻焦虑方面有效（SMD -0.35，95%CI -0.65至-0.05；I² 0%）。没有足够的证据就疲劳、关节疼痛、腹痛、压力和抑郁的变化得出结论。所有试验均认为体育活动是安全的。
PA有助于减轻静止期/轻度IBD患者的焦虑。在研究静止期/轻度IBD成年患者PA的试验中，方法学存在显著异质性。本综述强调了在该研究领域对PA类型和强度进行统一界定的必要性。
