Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Monastir, Tunisia.
Nat Prod Res. 2024 Nov;38(22):3881-3892. doi: 10.1080/14786419.2023.2266103. Epub 2023 Oct 9.
The purpose of this paper was to evaluate the phytochemical profile of trunk bark methanol extract using LC-MS/MS, as well as to assess its antioxidant and anti-tyrosinase activities. Thus, total phenolic and flavonoid contents of the studied extract were established and 19 compounds were detected and quantified. In addition of their antioxidant potential against DPPH and ABTS assays, and studies were adopted to evaluate tyrosinase inhibitory property of extract. Methanol trunk bark extract showed significant total phenolic content, antioxidant potential in terms of free radical scavenging, as well as an interesting tyrosinase inhibitory action (IC= 05.12 ± 0.41 μg/mL). The molecular docking analysis and the drug-likeness prediction of the major selected compounds supported the significant anti-tyrosinase activity of the studied extract. The obtained results suggest that extract could be a promising candidate in the treatment of skin hyperpigmentation disorders.
本文旨在利用 LC-MS/MS 评估树干皮甲醇提取物的植物化学成分谱，并评估其抗氧化和抗酪氨酸酶活性。因此，建立了研究提取物的总酚和类黄酮含量，并检测和定量了 19 种化合物。除了对 DPPH 和 ABTS 测定的抗氧化潜力外，还采用了研究来评估提取物的酪氨酸酶抑制特性。甲醇树干皮提取物表现出显著的总酚含量、自由基清除方面的抗氧化潜力，以及对酪氨酸酶的抑制作用（IC=05.12±0.41μg/mL）。主要选择化合物的分子对接分析和药物相似性预测支持了研究提取物的显著抗酪氨酸酶活性。研究结果表明，提取物可能是治疗皮肤色素沉着紊乱的有前途的候选药物。
