Chemical composition, antioxidant and anti-tyrosinase potentials of trunk bark using and approaches.

The purpose of this paper was to evaluate the phytochemical profile of trunk bark methanol extract using LC-MS/MS, as well as to assess its antioxidant and anti-tyrosinase activities. Thus, total phenolic and flavonoid contents of the studied extract were established and 19 compounds were detected and quantified. In addition of their antioxidant potential against DPPH and ABTS assays, and studies were adopted to evaluate tyrosinase inhibitory property of extract. Methanol trunk bark extract showed significant total phenolic content, antioxidant potential in terms of free radical scavenging, as well as an interesting tyrosinase inhibitory action (IC= 05.12 ± 0.41 μg/mL). The molecular docking analysis and the drug-likeness prediction of the major selected compounds supported the significant anti-tyrosinase activity of the studied extract. The obtained results suggest that extract could be a promising candidate in the treatment of skin hyperpigmentation disorders.