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A mucin degrader for cancer therapy.

作者信息

Beatson Richard, Burchell Joy M

机构信息

Centre for Inflammation and Tissue Repair, University College London, London, UK.

School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.

出版信息

Nat Biotechnol. 2024 Apr;42(4):572-573. doi: 10.1038/s41587-023-01984-5.

DOI:10.1038/s41587-023-01984-5
PMID:37813982
Abstract
摘要

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A mucin degrader for cancer therapy.一种用于癌症治疗的粘蛋白降解剂。
Nat Biotechnol. 2024 Apr;42(4):572-573. doi: 10.1038/s41587-023-01984-5.
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Mucin Glycans: A Target for Cancer Therapy.黏蛋白糖链：癌症治疗的新靶点
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Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer.黏蛋白（MUC1、MUC2、MUC3、MUC4、MUC5AC和MUC6）在人乳腺癌中的表达及其预后意义。
Mod Pathol. 2005 Oct;18(10):1295-304. doi: 10.1038/modpathol.3800445.
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Mucins and mucin binding proteins in colorectal cancer.结直肠癌中的黏蛋白和黏蛋白结合蛋白
Cancer Metastasis Rev. 2004 Jan-Jun;23(1-2):77-99. doi: 10.1023/a:1025815113599.
6
Genetic variants of mucins: unexplored conundrum.黏蛋白的基因变异：未被探索的难题。
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Mucins and Pathogenic Mucin-Like Molecules Are Immunomodulators During Infection and Targets for Diagnostics and Vaccines.黏蛋白和致病性黏蛋白样分子在感染过程中是免疫调节剂，也是诊断和疫苗的靶点。
Front Chem. 2019 Oct 22;7:710. doi: 10.3389/fchem.2019.00710. eCollection 2019.
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Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in mucinous carcinoma of the breast: comparison with invasive ductal carcinoma.乳腺黏液癌中黏蛋白（MUC1、MUC2、MUC5AC和MUC6）的表达：与浸润性导管癌的比较。
Histopathology. 2003 Jan;42(1):26-36. doi: 10.1046/j.1365-2559.2003.01530.x.
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Human fetal ductal plate revisited: II. MUC1, MUC5AC, and MUC6 are expressed in human fetal ductal plate and MUC1 is expressed also in remodeling ductal plate, remodeled ductal plate and mature bile ducts of human fetal livers.重新审视人类胎儿胆管板：II. MUC1、MUC5AC和MUC6在人类胎儿胆管板中表达，且MUC1也在人类胎儿肝脏的重塑胆管板、重塑后胆管板及成熟胆管中表达。
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Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas.人胃癌中MUC6粘蛋白表达及其他分泌性粘蛋白（MUC5AC和MUC2）共表达的免疫组织化学研究
J Histochem Cytochem. 2000 Mar;48(3):377-88. doi: 10.1177/002215540004800307.

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Cancer Gene Ther. 2025 Apr 29. doi: 10.1038/s41417-025-00911-x.
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Pulmonary mucinous adenocarcinoma: An overview of pathophysiology and advancements in treatment.肺黏液腺癌：病理生理学概述与治疗进展
Heliyon. 2024 Mar 29;10(9):e28881. doi: 10.1016/j.heliyon.2024.e28881. eCollection 2024 May 15.

本文引用的文献

1
Design of a mucin-selective protease for targeted degradation of cancer-associated mucins.设计一种粘蛋白选择性蛋白酶，用于靶向降解与癌症相关的粘蛋白。
Nat Biotechnol. 2024 Apr;42(4):597-607. doi: 10.1038/s41587-023-01840-6. Epub 2023 Aug 3.
2
PROTAC targeted protein degraders: the past is prologue.PROTAC 靶向蛋白降解剂：过去是序幕。
Nat Rev Drug Discov. 2022 Mar;21(3):181-200. doi: 10.1038/s41573-021-00371-6. Epub 2022 Jan 18.
3
Latest developments in MUC1 immunotherapy.MUC1 免疫疗法的最新进展。
Biochem Soc Trans. 2018 Jun 19;46(3):659-668. doi: 10.1042/BST20170400. Epub 2018 May 21.
4
Cancer glycan epitopes: biosynthesis, structure and function.癌症糖基表位：生物合成、结构和功能。
Glycobiology. 2018 Sep 1;28(9):670-696. doi: 10.1093/glycob/cwy023.
5
Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells.半乳糖凝集素-3 与细胞表面 MUC1 的相互作用促进了人上皮癌细胞中 EGFR 的二聚化和激活。
Cell Death Differ. 2017 Nov;24(11):1937-1947. doi: 10.1038/cdd.2017.119. Epub 2017 Jul 21.
6
The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9.黏蛋白MUC1通过凝集素Siglec-9的结合来调节肿瘤免疫微环境。
Nat Immunol. 2016 Nov;17(11):1273-1281. doi: 10.1038/ni.3552. Epub 2016 Sep 5.
7
The cancer glycocalyx mechanically primes integrin-mediated growth and survival.癌症糖萼通过机械作用引发整合素介导的生长和存活。
Nature. 2014 Jul 17;511(7509):319-25. doi: 10.1038/nature13535. Epub 2014 Jun 25.
8
MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches.MUC1-C 癌蛋白作为乳腺癌的治疗靶点：信号通路的激活与治疗方法。
Oncogene. 2013 Feb 28;32(9):1073-81. doi: 10.1038/onc.2012.158. Epub 2012 May 14.