School of Medicine, Fu-Jen Catholic University, New Taipei City, 24205, Taiwan.
Department of Radiology, Cathay General Hospital, No.280 Sec 4 Ren-Ai Rd, Taipei, 10630, Taiwan.
BMC Med Imaging. 2023 Oct 9;23(1):151. doi: 10.1186/s12880-023-01110-6.
The safety and efficacy of 17-gauge needles used in CT-guided percutaneous cryoablation for lung nodules were explored in this study. The purpose of the study was to compare the findings with earlier research and multi-center clinical trials that used various needle sizes.
Between 2016 and 2020, a retrospective study was conducted with approval from the institutional review board. A total of 41 patients were enrolled, and 71 lung nodules were treated in 63 cryoablation procedures using local anesthesia. Complication rates were recorded, and overall survival rates as well as tumor progression-free rates were calculated using the Kaplan-Meier method.
Self-limited hemoptysis was caused by 12.9% of the procedures, and drainage was required for pneumothoraces resulting from 11.3% of them. The overall survival rates at one, two, three, and four years were 97%, 94%, 82%, and 67%, respectively. The tumor progression-free rates at one, two, three, and four years were 86.2%, 77%, 74%, and 65%, respectively.
Cryoablation for lung nodules using 17-Gauge needles can achieve similar rates of survival and tumor control rates, similar or even lower complication rates as compared with other studies and multi-center trials using mixed sized needles.
本研究旨在探讨 CT 引导下经皮冷冻消融治疗肺结节时使用 17 号针的安全性和有效性，并将其结果与之前使用不同大小的针进行的研究和多中心临床试验进行比较。
本回顾性研究于 2016 年至 2020 年进行，获得了机构审查委员会的批准。共纳入 41 例患者，在 63 次局部麻醉下冷冻消融治疗中处理了 71 个肺结节。记录并发症发生率，并使用 Kaplan-Meier 法计算总生存率和肿瘤无进展生存率。
12.9%的手术导致自限性咯血，11.3%的手术导致气胸需要引流。1、2、3、4 年的总生存率分别为 97%、94%、82%和 67%。1、2、3、4 年的肿瘤无进展生存率分别为 86.2%、77%、74%和 65%。
与使用混合大小的针进行的其他研究和多中心试验相比，使用 17 号针进行肺结节冷冻消融可以获得相似的生存率和肿瘤控制率，相似甚至更低的并发症发生率。
