Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, China.
College of Medicine, Southwest Jiaotong University, Chengdu, China.
J Clin Hypertens (Greenwich). 2023 Nov;25(11):1019-1026. doi: 10.1111/jch.14730. Epub 2023 Oct 9.
Serum uric acid (UA), as an antioxidant, has been associated with hypertension in the general population. Hypertension is highly prevalent in patients with polymyositis and dermatomyositis (PM/DM). Owning elevated levels of reactive oxygen species, patients with PM/DM have lower concentrations of UA in comparison with healthy people. We explored a potential association between UA levels and hypertension in PM/DM and evaluated whether this association is independent of hypertension risk factors, PM/DM characteristics and relevant drugs. A total of 472 PM/DM patients were assessed. UA and related laboratory data were measured. Demographic, hypertension-related factors, PM/DM characteristics and drug use were assessed as potential covariates. Results were analyzed using logistic models to test the independence of the association between UA and hypertension. UA levels were higher in hypertension subjects compared to non-hypertensive PM/DM patients [284.70 (239.93-357.38) vs 264.00(222.50-322.75), p = .017]. When adjusted for hypertension risk factors, PM/DM characteristics and drugs, the odds of being a hypertensive PM/DM patient per 1 μmol/L UA increase were significantly increased: odds ratio = 1.473 (95% confidence interval:1.063-2.042, p = .020). This cross-sectional study suggests that UA levels are independently associated with hypertension in PM/DM patients.
血清尿酸（UA）作为一种抗氧化剂，与普通人群中的高血压有关。多发性肌炎和皮肌炎（PM/DM）患者中高血压的患病率很高。与健康人相比，患有 PM/DM 的患者由于活性氧（ROS）水平升高，UA 浓度较低。我们探讨了 UA 水平与 PM/DM 中高血压之间的潜在关联，并评估了这种关联是否独立于高血压危险因素、PM/DM 特征和相关药物。评估了 472 例 PM/DM 患者。测量了 UA 和相关实验室数据。评估了人口统计学、与高血压相关的因素、PM/DM 特征和药物使用情况作为潜在的协变量。使用逻辑模型分析结果，以测试 UA 与高血压之间关联的独立性。与非高血压 PM/DM 患者相比，高血压患者的 UA 水平更高[284.70（239.93-357.38）比 264.00（222.50-322.75），p=0.017]。在校正高血压危险因素、PM/DM 特征和药物后，UA 每增加 1μmol/L，成为高血压 PM/DM 患者的几率明显增加：比值比=1.473（95%置信区间：1.063-2.042，p=0.020）。这项横断面研究表明，UA 水平与 PM/DM 患者的高血压独立相关。
