血清尿酸和甘油三酯在新发烟雾病中国患者中的变化：一项横断面研究。
Serum Uric Acid and Triglycerides in Chinese Patients with Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study.
机构信息
Clinical Medical College, Jining Medical University, Jining, Shandong 272067, China.
Department of Neurosurgery, Affiliated Hospital of Jining Medical University & Shandong Provincial Key Laboratory of Stem Cells and Neuro-oncology, Jining, Shandong 272029, China.
出版信息
Biomed Res Int. 2019 Jul 2;2019:9792412. doi: 10.1155/2019/9792412. eCollection 2019.
BACKGROUND
Evidence regarding the relationship between serum uric acid and triglycerides is limited. Therefore, the specific objective of this study was to investigate whether serum uric acid was independently related to triglycerides in Chinese patients with newly diagnosed moyamoya disease after adjusting for other covariates.
METHODS
The present study was a cross-sectional study. A total of 261 Chinese patients with newly diagnosed moyamoya disease were recruited from a hospital in China from 24 March 2013 to 24 December 2018. The independent variable and the dependent variable were serum uric acid measured at baseline and triglycerides, respectively. The covariates involved in this study included age, sex, body mass index, smoking status, and alcohol consumption.
RESULTS
The average age of the 227 selected participants was 47.5 ± 12.6 years old, and approximately 48.5% of them were male. The results of the fully adjusted linear regression showed that serum uric acid (10 mol/L) was positively associated with triglycerides (mmol/L) after adjusting for confounders ( 0.048, 95% CI 0.032, 0.064).
CONCLUSIONS
In patients with moyamoya disease, there seemed to be a positive association between serum uric acid and triglycerides.
背景
关于血清尿酸与甘油三酯之间关系的证据有限。因此，本研究的具体目的是在调整其他协变量后，探讨血清尿酸是否与中国新发烟雾病患者的甘油三酯独立相关。
方法
本研究为横断面研究。2013 年 3 月 24 日至 2018 年 12 月 24 日，我们从中国的一家医院招募了 261 例新发烟雾病的中国患者。基线时测量的血清尿酸为自变量，甘油三酯为因变量。本研究涉及的协变量包括年龄、性别、体重指数、吸烟状况和饮酒状况。
结果
在 227 名入选者中，平均年龄为 47.5±12.6 岁，约 48.5%为男性。经混杂因素校正后，全调整线性回归显示，血清尿酸（10μmol/L）与甘油三酯（mmol/L）呈正相关（0.048，95%CI 0.032，0.064）。
结论
在烟雾病患者中，血清尿酸与甘油三酯之间似乎存在正相关。
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