Aghdashi Miramir, Behnemoon Mahsa, Mahmoodi Rad Jila, Rabiepour Masoumeh
Urmia University of Medical Sciences, Urmia, Iran.
Biomedicine (Taipei). 2018 Sep;8(3):16. doi: 10.1051/bmdcn/2018080316. Epub 2018 Aug 24.
Systemic lupus erythematosus (SLE) is a life-threatening multisystem inflammatory condition affected any organ system. Considering the role of uric acid as a pro-inflammatory compound in high pulmonary arterial pressure, serum levels of uric acid and its relation to severity and duration of the disease were assessed in SLE patients.
As a cross-sectional study, 75 patients with SLE were enrolled in Imam Khomeini Hospital and Sahand Clinic. Serum uric acid level was measured by pars azmoon kit. Pearson correlation coefficient and T-test were used for statistical analysis of data.
The mean duration of SLE was 56.44 ± 40.57 months. High serum uric acid was observed in 13.3% of patients with SLE. Moreover, 8% of these patients had high pulmonary arterial pressure. Serum uric acid in patients with high pulmonary artery pressure was significantly higher than patients with normal pulmonary artery pressure (P < 0.01). Furthermore, a significant relation was seen between severity of SLE disease with serum uric acid level and pulmonary artery systolic pressure (P < 0.05). However, there was no significant correlation between serum uric acid level and duration of the disease (p = 0.90, r = 0.016).
According to these results, a significantly increased level of serum uric acid was observed in patients with pulmonary arterial pressure. Hence, serum uric acid level could be a prognostic marker of pulmonary arterial pressure in SLE patients which correlates with disease severity. It also would help to reduce clinical demands for echocardiography in patients with normal uric acid levels.
系统性红斑狼疮（SLE）是一种危及生命的多系统炎症性疾病，可累及任何器官系统。鉴于尿酸作为促炎化合物在高肺动脉压中的作用，本研究评估了SLE患者的血清尿酸水平及其与疾病严重程度和病程的关系。
作为一项横断面研究，75例SLE患者被纳入伊玛目霍梅尼医院和萨汉德诊所。采用Pars Azmoon试剂盒测定血清尿酸水平。数据采用Pearson相关系数和T检验进行统计分析。
SLE的平均病程为56.44±40.57个月。13.3%的SLE患者血清尿酸水平升高。此外，这些患者中有8%患有高肺动脉压。肺动脉压高的患者血清尿酸水平显著高于肺动脉压正常的患者（P<0.01）。此外，SLE疾病的严重程度与血清尿酸水平和肺动脉收缩压之间存在显著相关性（P<0.05）。然而，血清尿酸水平与疾病病程之间无显著相关性（p = 0.90，r = 0.016）。
根据这些结果，肺动脉压患者的血清尿酸水平显著升高。因此，血清尿酸水平可能是SLE患者肺动脉压的一个预后标志物，与疾病严重程度相关。这也将有助于减少尿酸水平正常患者的超声心动图临床需求。
