粪便微生物群移植治疗复发性艰难梭菌感染：连续病例系列中的围手术期方法。
Treatment of recurrent Clostridioides difficile infections with faecal microbiota transplantation: peri-procedural methods in a consecutive case series.
机构信息
Department of Geriatric Medicine, C.H.U. de Charleroi, ISPPC, Charleroi, Belgium.
Laboratory of Experimental Medicine, ULB 222 Unit, C.H.U. de Charleroi, A. Vésale Hospital,Université Libre de Bruxelles, Montigny-le-Tilleul, Belgium.
出版信息
Acta Gastroenterol Belg. 2023 Jul-Sep;86(3):486-489. doi: 10.51821/86.3.11795.
BACKGROUND
Faecal microbiota transplantation (FMT) has high efficacy against recurrent Clostridioides difficile infection (CDI). Despite the increasing use of this therapy, the delay between diagnosis and treatment is excessive. Furthermore, donor selection is an important and time-consuming process.
METHODS
We reviewed patients who underwent FMT for recurrent CDI at the CHU Charleroi Hospital between 2015 and 2022. The general context, type of administration, adverse events, and donor selection were reported. FMT was conducted using gastroduodenoscopy, colonoscopy, and enema with either fresh or frozen material.
RESULTS
Ten patients with multiple comorbidities were treated by FMT. Seven patients were cured after one procedure. One patient was successfully cured after a change to an unrelated donor, and preliminary efficacy was established.
CONCLUSIONS
FMT is an effective treatment that should be considered during the earlier phases of treatment. Stool donors should be thoroughly screened for infectious diseases and other criteria related to microbiota composition.
背景
粪便微生物群移植（FMT）对复发性艰难梭菌感染（CDI）具有很高的疗效。尽管这种治疗方法的应用越来越多，但诊断和治疗之间的时间延迟过长。此外，供体选择是一个重要且耗时的过程。
方法
我们回顾了 2015 年至 2022 年间在 CHARLEROI 医院接受 FMT 治疗复发性 CDI 的患者。报告了一般情况、管理类型、不良反应和供体选择。FMT 通过胃镜、结肠镜和灌肠进行，使用新鲜或冷冻材料。
结果
10 例合并多种疾病的患者接受了 FMT 治疗。7 例患者在一次手术后痊愈。1 例患者在更换无关供体后成功治愈，初步疗效确立。
结论
FMT 是一种有效的治疗方法，应在治疗的早期阶段考虑。粪便供体应彻底筛查传染病和其他与微生物群组成相关的标准。
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