Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Pharmaceutics, Shanghai Eighth People's Hospital, Shanghai, China.
Expert Opin Drug Deliv. 2023 Jul-Dec;20(11):1467-1488. doi: 10.1080/17425247.2023.2268512. Epub 2023 Dec 20.
Intravenous nanocrystals (INCs) have shown intrinsic advantages in antitumor applications, particularly their properties of high drug loading, low toxicity, and controllable size. Therefore, it has a very bright application prospect as a drug delivery system.
The ideal formulation design principles, fabrication, solidification, in vivo fate of INCs, the applications in drug delivery system (DDS) and the novel applications are covered in this review.
It is vital to select a suitable formulation and fabrication method to produce a stable and sterile INCs. Besides, the type of stabilizers and physical characteristics can also influence the in vivo fate of INCs, which is worthy of further studying. Based on wide researches about applications of INCs in cancer, biomimetic INCs are concerned increasingly for its favorable compatibility. The output of these studies suggested that INCs-based drug delivery could be a novel strategy for addressing the delivery of the drug that faces solubility, bioavailability, and toxicity problems.
静脉内纳米晶体（INCs）在抗肿瘤应用中具有内在优势，特别是其高载药量、低毒性和可控尺寸的特性。因此，作为药物传递系统，它具有非常广阔的应用前景。
本文综述了理想的制剂设计原则、制备、固化、INCs 的体内命运、在药物传递系统（DDS）中的应用以及新的应用。
选择合适的制剂和制备方法来生产稳定和无菌的 INCs 至关重要。此外，稳定剂的类型和物理特性也会影响 INCs 的体内命运，这值得进一步研究。基于 INCs 在癌症中的广泛应用研究，仿生 INCs 因其良好的相容性而受到越来越多的关注。这些研究的结果表明，基于 INCs 的药物传递可能是解决药物面临的溶解度、生物利用度和毒性问题的一种新策略。
