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源自乌尔米湖的抗菌活性。

Antibacterial activity of Lake Urmia derived-.

作者信息

Sadati Razieh, Shaykh-Baygloo Nima, Shokri Rasoul

机构信息

Department of Microbiology, Faculty of Science, Zanjan Branch, Islamic Azad University, Zanjan, Iran.

Department of Biology, Faculty of Science, Urmia University, Urmia, Iran.

出版信息

Vet Res Forum. 2023;14(9):515-523. doi: 10.30466/vrf.2022.556550.3526. Epub 2023 Sep 15.

DOI:10.30466/vrf.2022.556550.3526
PMID:37814661
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10560322/
Abstract

Isolation of new microbial species from extreme environments is one of the most efficient approaches for the development of novel bioactive metabolites. The aim of the present study was to explore the pharmaceutical bacterial resources from the water and sediments of hypersaline Lake Urmia. Using different culture conditions and media led to the isolation of 20 bacterial strains. Halophilic bacteria were screened for the production of antibacterial agent against multi-drug resistant strains of through agar well diffusion assay. Halophilic bacteria DNA extraction was done by boiling method. The results showed that two strains, LUH16 and LUH20 identified by analysis of 16S rRNA gene sequences were the potent producers of antimicrobial metabolites against various strains of . Furthermore, gas chromatography-mass spectrometry (GC-MS) analysis revealed the presence of eight secondary metabolites with the relevant antimicrobial properties. Our findings led us to focus on strains as potent producers of antimicrobial compound that might be an alternative against antibiotic-resistant pathogens such as pathogenic .

摘要

从极端环境中分离新的微生物物种是开发新型生物活性代谢物最有效的方法之一。本研究的目的是探索乌尔米耶盐湖水体和沉积物中的药用细菌资源。采用不同的培养条件和培养基分离出20株细菌菌株。通过琼脂扩散法筛选嗜盐细菌对多重耐药菌株的抗菌剂产生情况。嗜盐细菌DNA提取采用煮沸法。结果表明，通过16S rRNA基因序列分析鉴定的两株菌株LUH16和LUH20是针对各种菌株的抗菌代谢物的有效生产者。此外，气相色谱-质谱（GC-MS）分析显示存在八种具有相关抗菌特性的次生代谢物。我们的研究结果使我们将重点放在作为抗菌化合物有效生产者的菌株上，这些化合物可能是对抗诸如致病性等抗生素耐药病原体的替代品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2165/10560322/84a27fdff784/vrf-14-515-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2165/10560322/d0c12b272d68/vrf-14-515-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2165/10560322/72e94390032e/vrf-14-515-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2165/10560322/33240c345208/vrf-14-515-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2165/10560322/84a27fdff784/vrf-14-515-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2165/10560322/d0c12b272d68/vrf-14-515-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2165/10560322/72e94390032e/vrf-14-515-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2165/10560322/33240c345208/vrf-14-515-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2165/10560322/84a27fdff784/vrf-14-515-g004.jpg

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