Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, National Demonstration Center for Experimental Chemistry Education, Northwest University, Xi'an, Shaanxi 710127, China.
College of Food Science and Technology, Northwest University, Xi'an, Shaanxi 710069, China.
Food Funct. 2023 Oct 30;14(21):9707-9724. doi: 10.1039/d3fo01893h.
Walnut Oil (WO) is recognized for its potential to improve cognition, but the mechanisms of its action related to improving cognitive impairment are not yet clear. In this study, the components of walnut oil were measured, and it was found that WO supplementation for 8 weeks could significantly prevent cognitive behavioral deficits and synaptic dysfunction induced by intraperitoneal injection of scopolamine (SCOP) in mice. By comparing and analyzing the changes in the hippocampal synaptic structure, oxidative stress, neurotransmitter fluctuations, brain transcriptome, inflammatory factors and gut microbiota in mice from different treatment groups, we observed a significant correlation between synaptic transmission genes, gut microbiota and neurotransmission in the WO supplemented group. It was found that WO supplementation could influence the secretion of neurotransmitters Ach and 5-HT by modulating the gut microbiota , thereby improving cognitive impairment through the central nervous system and hypothalamic-pituitary-adrenal (HPA) axis regulation.
核桃油（Walnut Oil，WO）因其改善认知能力的潜力而受到认可，但与改善认知障碍相关的作用机制尚不清楚。在本研究中，测量了核桃油的成分，发现 WO 补充 8 周可显著预防腹腔注射东莨菪碱（scopolamine，SCOP）诱导的小鼠认知行为缺陷和突触功能障碍。通过比较和分析来自不同治疗组小鼠的海马突触结构、氧化应激、神经递质波动、脑转录组、炎症因子和肠道微生物组的变化，我们观察到补充 WO 组的突触传递基因、肠道微生物组和神经递质之间存在显著相关性。研究发现，WO 补充可通过调节肠道微生物组来影响神经递质 Ach 和 5-HT 的分泌，从而通过中枢神经系统和下丘脑-垂体-肾上腺（Hypothalamic-Pituitary-Adrenal，HPA）轴调节来改善认知障碍。
