Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi, China.
Anhui Kangxinxiang Agricultural Technology Co., Ltd, Yuexi 246600, Anhui, China.
Food Funct. 2023 Nov 27;14(23):10520-10534. doi: 10.1039/d3fo03800a.
The oil of (TGO), a common nut in China, is considered to be a bioactive edible oil and has a great value in functional food development. In this study, the neuroprotective effects of TGO were investigated on a scopolamine (SCOP)-induced C57BL/6J mouse model. The mice were pretreated with TGO for 30 days (1000 mg per kg per day and 3000 mg per kg per day, i.g.). Behavioral tests showed that the supplementation of TGO could prevent the cognitive deficits induced by SCOP. TGO rebalanced the disorder of the cholinergic system by upgrading the level of acetylcholine. TGO also alleviated the over-activation of microglia and inhibited neuroinflammation and oxidative stress. Additionally, TGO could regulate the composition of gut microbiota, increase the production of short-chain fatty acids, and decrease the content of lipopolysaccharides in the serum. In conclusion, TGO has the potential to prevent loss of memory and impairment of cognition, which may be related to its regulation of the gut microbiota-metabolite-brain axis.
中国常见坚果油桐（TGO）油被认为是一种具有生物活性的食用油，在功能性食品开发方面具有很大的价值。本研究探讨了 TGO 对东莨菪碱（SCOP）诱导的 C57BL/6J 小鼠模型的神经保护作用。小鼠用 TGO 预处理 30 天（1000mg/kg/天和 3000mg/kg/天，ig）。行为学测试表明，TGO 补充可预防 SCOP 诱导的认知功能障碍。TGO 通过提高乙酰胆碱水平来平衡胆碱能系统的紊乱。TGO 还减轻了小胶质细胞的过度激活，并抑制了神经炎症和氧化应激。此外，TGO 可以调节肠道微生物群的组成，增加短链脂肪酸的产生，并降低血清中脂多糖的含量。总之，TGO 具有预防记忆丧失和认知障碍的潜力，这可能与其调节肠道微生物群-代谢物-脑轴有关。
