Asaulenko Z P, Spiridonov I N, Baram D V, Krivolapov Yu A
St. Petersburg City Hospital No 40, St. Petersburg, Russia.
Russian Research Institute of Hematology and Transfusiology, St. Petersburg, Russia.
Arkh Patol. 2023;85(5):36-44. doi: 10.17116/patol20238505136.
The article reviews the changes in the structure of classification, diagnostic criteria for myeloid and histiocytic neoplasms in the 5 edition of the WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues (2022). Information is presented regarding new nosological forms, renaming and abolition of some previously existing ones. The importance of molecular genetic studies in the isolation of myeloid and histiocytic neoplasms and the need to apply these studies in clinical practice are emphasized. Myeloid and histiocytic precancerous and proliferative processes, genetic tumor syndromes, introduced into the classification for the first time, are considered.
本文回顾了《世界卫生组织造血与淋巴组织肿瘤分类》第5版(2022年)中髓系和组织细胞肿瘤的分类结构变化、诊断标准。介绍了有关新病种形式、一些既往存在病种的重新命名和废除的信息。强调了分子遗传学研究在髓系和组织细胞肿瘤鉴别诊断中的重要性以及在临床实践中应用这些研究的必要性。文中还讨论了首次纳入分类的髓系和组织细胞癌前病变及增殖性病变、遗传性肿瘤综合征。