调节性 T 细胞能控制皮肤细菌和与 IFN-γ 相关的病理。
Tregs tame skin bacteria and IFN-γ-associated pathology.
机构信息
Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.
出版信息
J Exp Med. 2023 Dec 4;220(12). doi: 10.1084/jem.20231571. Epub 2023 Oct 10.
Mibrobial dysbiosis worsens cutaneous leishmaniasis. In this issue of JEM, Singh et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230558) show that Rorγt+ regulatory T cells suppress pathogenic IFN-γ responses to control Staphylococcus aureus growth and limit S. aureus- and Leishmamia braziliensis-associated immunopathology at the skin barrier.
微生物失调会使皮肤利什曼病恶化。在本期《实验医学杂志》上，Singh 等人（2023. J. Exp. Med.https://doi.org/10.1084/jem.20230558）表明，Rorγt+调节性 T 细胞抑制致病性 IFN-γ 反应，以控制金黄色葡萄球菌的生长，并限制皮肤屏障处金黄色葡萄球菌和巴西利什曼原虫相关的免疫病理。
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