Bell R T, Lippmann M
Arch Intern Med. 1979 Jul;139(7):817-9. doi: 10.1001/archinte.139.7.817.
Immediately following the initial ingestion of hydrochlorothiazide, acute pulmonary edema developed in a patient who previously used bendroflumethiazide. Unlike previously published reports, we studied the patient from immunologic and pulmonary function aspects. Using standard techniques, no significant immunological mechanisms could be demonstrated. The pulmonary function testing disclosed a widened alveolar-arterial oxygen gradient and mildly decreased diffusing capacity that cleared on serial testing. We believe that this demonstrates a rare idiosyncratic reaction that apparently is seen specifically with hydrochlorothiazide and not with other thiazide medications.
在一名先前使用过苄氟噻嗪的患者首次摄入氢氯噻嗪后，随即发生了急性肺水肿。与先前发表的报告不同，我们从免疫学和肺功能方面对该患者进行了研究。采用标准技术，未发现明显的免疫机制。肺功能测试显示肺泡-动脉血氧梯度增宽，弥散能力轻度下降，多次测试后恢复正常。我们认为，这表明了一种罕见的特异反应，显然这种反应是氢氯噻嗪特有的，而非其他噻嗪类药物。
