Andresen Max, González Alejandro, Espino Alberto, Mercado Marcelo, Regueira Tomas, Dougnac Alberto
Programa de Medicina Intensiva, Unidad de Tratamiento Intensivo Médico, Hospital Clínico, Pontificia Universidad Católica de Chile, Chile.
Rev Med Chil. 2007 Apr;135(4):496-500. doi: 10.4067/s0034-98872007000400012. Epub 2007 May 16.
Acute pulmonary edema caused by thiazides is uncommon and of difficult diagnosis. It is considered an idiosyncratic reaction and the physiopathology or cardiac function changes are not well known. We report a 60 year-old female with a thiazide induced acute pulmonary edema who was followed with serial measurements of type B n-terminal natriuretic peptide fraction as marker for cardiac dysfunction. There was a significant elevation of the peptide, not associated to evidences of ventricular dysfunction. Its normalization paralleled the resolution of the clinical picture.
噻嗪类药物引起的急性肺水肿并不常见且诊断困难。它被认为是一种特异反应，其生理病理学或心脏功能变化尚不明确。我们报告一例60岁女性，因噻嗪类药物诱发急性肺水肿，我们连续测量B型氨基末端利钠肽前体作为心脏功能障碍的标志物对其进行随访。该肽显著升高，与心室功能障碍的证据无关。其恢复正常与临床表现的缓解同步。
