Hospital Santa Creu i Sant Pau, Biomedical Research Institute IIB-Sant Pau, Barcelona, Spain.
Expert Rev Cardiovasc Ther. 2023 Jul-Dec;21(10):703-712. doi: 10.1080/14779072.2023.2266368. Epub 2023 Oct 26.
With the expanding indications of transcatheter aortic valve replacement (TAVR) to younger and low-risk patients, the life expectancy of patients currently undergoing TAVR will likely outlive the durability of transcatheter bioprosthesis. Consequently, the number of failed transcatheter bioprosthesis requiring surgical valve explant or redo TAVR is expected to increase.
The aim of this review is to provide an updated overview of redo TAVR for treating degenerated transcatheter bioprosthesis, focusing on pre-procedural planning, potential challenges of coronary reaccess during TAVR-in-TAVR and main outcomes of TAVR explant and redo TAVR.
Patient-tailored device selection and individualized implantation height should be carefully assessed during the index TAVR procedure (weighting between pacemaker avoidance and the potential risk of coronary occlusion in future TAVR-in-TAVR). Future prospective studies comparing safety and clinical outcomes between redo TAVR vs TAVR explant are eagerly awaited.
随着经导管主动脉瓣置换术(TAVR)适应证向年轻和低危患者扩展,目前接受 TAVR 的患者的预期寿命可能会超过经导管生物瓣的耐久性。因此,需要手术瓣膜取出或再次 TAVR 来治疗失败的经导管生物瓣的数量预计将会增加。
本综述的目的是提供一个关于经导管生物瓣退行性病变的再次 TAVR 治疗的最新概述,重点介绍 TAVR 瓣中瓣和 TAVR 瓣取出及再次 TAVR 的术前规划、再次 TAVR 期间冠状动脉再进入的潜在挑战和主要结果。
在指数 TAVR 手术期间,应仔细评估个体化的器械选择和植入高度(在避免起搏器和未来 TAVR 瓣中瓣时冠状动脉闭塞的潜在风险之间进行权衡)。未来需要前瞻性研究来比较再次 TAVR 与 TAVR 瓣取出的安全性和临床结果。