Department of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine, Harbin, 150040, China.
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150040, China.
J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117299. doi: 10.1016/j.jep.2023.117299. Epub 2023 Oct 8.
As a "silent killer" that threatens women's lives and health, ovarian cancer (OC) has the clinical characteristics of being difficult to detect, difficult to treat, and high recurrence. Traditional Chinese medicine (TCM) can be utilized as a long-term complementary and alternative therapy since it has shown benefits in alleviating clinical symptoms of OC, decreasing toxic side effects of radiation and chemotherapy, as well as enhancing patients' quality of life.
This paper reviews how TCM contributes to the apoptosis of OC cells through signaling pathways, including active constituents, extracts, and herbal formulas, with the aim of providing a basis for the development and clinical application of therapeutic strategies for TCM in OC.
The search was conducted from scientific databases PubMed, Embase, Web of Science, CNKI, Wanfang, VIP, and SinoMed databases aiming to elucidate the apoptosis signaling pathways in OC cells by TCM. The articles were searched by the keywords "ovarian cancer", "apoptosis", "signaling pathway", "traditional Chinese medicine", "Chinese herbal monomer", "Chinese herbal extract", and "herbal formula". The search was conducted from January 2013 to June 2023. A total of 97 potentially relevant articles were included, including 93 articles on Chinese medicine active constituents or extracts and 4 articles on Chinese herbal compound prescriptions.
TCM can induce apoptosis in OC cells by regulating signaling pathways with obvious advantages, including STAT3, PI3K/AKT, Wnt/β-catenin, MAPK, NF-κB, Nrf2, HIF-1α, Fas/Fas L signaling pathway, etc. CONCLUSION: Chinese medicine can induce apoptosis in OC cells through multiple pathways, targets, and routes. TCM has special advantages for treating OC, providing more reasonable evidence for the research and development of new apoptosis inducers.
卵巢癌（OC）是一种威胁女性生命和健康的“沉默杀手”，具有难以发现、难以治疗和高复发的临床特点。中药（TCM）可以作为一种长期的补充和替代疗法，因为它在缓解 OC 的临床症状、降低放化疗的毒性副作用以及提高患者生活质量方面显示出了益处。
本文综述了 TCM 通过信号通路促进 OC 细胞凋亡的作用，包括活性成分、提取物和方剂，旨在为 TCM 在 OC 治疗策略的开发和临床应用提供依据。
从科学数据库 PubMed、Embase、Web of Science、CNKI、万方、VIP 和 SinoMed 中检索 TCM 对 OC 细胞凋亡信号通路的作用，检索词为“卵巢癌”、“凋亡”、“信号通路”、“中药”、“中药单体”、“中药提取物”和“方剂”。检索时间为 2013 年 1 月至 2023 年 6 月。共纳入 97 篇潜在相关文献，其中 93 篇为中药活性成分或提取物，4 篇为中药复方方剂。
TCM 可以通过调节信号通路诱导 OC 细胞凋亡，具有明显的优势，包括 STAT3、PI3K/AKT、Wnt/β-catenin、MAPK、NF-κB、Nrf2、HIF-1α、Fas/FasL 等信号通路。
中药可以通过多种途径、靶点和途径诱导 OC 细胞凋亡。中药在治疗 OC 方面具有特殊优势，为新凋亡诱导剂的研究和开发提供了更合理的证据。
