Panuccio P, Cresci F, Fontana G, Mugnai M, Gizdulich P
Int J Clin Pharmacol Res. 1986;6(5):379-87.
The purpose of this paper, after a brief review of the main features of bronchoprovocation challenges, was to determine whether the administration of an ultrasonic mist of distilled water can influence the bronchial tone of normal subjects and patients affected by various respiratory disorders, in order to assess the effectiveness of this bronchoprovocation test in discriminating between patients. Of the 129 subjects tested 13 were classified as normal, 60 as extrinsic asthmatics, 21 as intrinsic asthmatics, 25 as allergic rhinitics and 37 as chronic bronchitics. Ultrasonic mist, was administered for 5 min and the bronchial response was evaluated in terms of difference between that after the mist minus baseline values of specific airways conductance. The data suggest that the bronchial challenge with ultrasonic mist, a safe, non-pharmacological and simple test, allows a good discrimination between asthma patients and those affected by other respiratory disorders.
在简要回顾支气管激发试验的主要特征之后，本文的目的是确定给予蒸馏水超声雾化是否会影响正常受试者以及患有各种呼吸系统疾病患者的支气管张力，以便评估这种支气管激发试验在区分患者方面的有效性。在接受测试的129名受试者中，13名被归类为正常，60名是外源性哮喘患者，21名是内源性哮喘患者，25名是变应性鼻炎患者，37名是慢性支气管炎患者。给予超声雾化5分钟，并根据雾化后与特定气道传导率基线值之间的差异来评估支气管反应。数据表明，超声雾化支气管激发试验是一种安全、非药物且简单的测试，能够很好地区分哮喘患者和其他呼吸系统疾病患者。
