Boulet L-P, Gauvreau G, Boulay M-E, O'Byrne P, Cockcroft D W
Unité de recherche en pneumologie, Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l'Université Laval, QC, Canada.
Allergy. 2007 Oct;62(10):1101-10. doi: 10.1111/j.1398-9995.2007.01499.x.
Allergen bronchoprovocation tests have been used for more than two decades in the investigation of respiratory allergic diseases such as asthma and rhinitis. These bronchial challenges are now well standardized and can offer key information on the therapeutic potential of new agents and on their anti-inflammatory effects on the airways. Both standard and low-dose allergen provocations are safe when performed by experienced investigators and do not lead to persistent worsening of asthma or change in airway function. The evaluation of new therapeutic agents by these methods can also provide important information on the mechanisms of development and persistence of airway diseases.
变应原支气管激发试验在哮喘和鼻炎等呼吸道过敏性疾病的研究中已应用了二十多年。目前这些支气管激发试验已得到很好的标准化，能够提供有关新药物治疗潜力及其对气道抗炎作用的关键信息。当由经验丰富的研究人员进行时，标准剂量和低剂量变应原激发试验都是安全的，不会导致哮喘持续恶化或气道功能改变。通过这些方法对新治疗药物进行评估，也可以提供有关气道疾病发生和持续机制的重要信息。
