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SARS-CoV-2 感染综合风险评估

Comprehensive Risk Assessment of Infection Induced by SARS-CoV-2.

机构信息

Toxicology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (Govt. of India), Poojapura, Trivandrum, Kerala, 695 012, India.

CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh, 160036, India.

出版信息

Mol Neurobiol. 2024 Dec;61(12):9851-9872. doi: 10.1007/s12035-023-03682-4. Epub 2023 Oct 11.

DOI:10.1007/s12035-023-03682-4
PMID:37817031
Abstract

The pandemic COVID-19 (coronavirus disease 2019) is caused by the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), which devastated the global economy and healthcare system. The infection caused an unforeseen rise in COVID-19 patients and increased the mortality rate globally. This study gives an overall idea about host-pathogen interaction, immune responses to COVID-19, recovery status of infection, targeted organs and complications associated, and comparison of post-infection immunity in convalescent subjects and non-infected individuals. The emergence of the variants and episodes of COVID-19 infections made the situation worsen. The timely introduction of vaccines and precautionary measures helped control the infection's severity. Later, the population that recovered from COVID-19 grew significantly. However, understanding the impact of healthcare issues resulting after infection is paramount for improving an individual's health status. It is now recognised that COVID-19 infection affects multiple organs and exhibits a broad range of clinical manifestations. So, post COVID-19 infection creates a high risk in individuals with already prevailing health complications. The identification of post-COVID-19-related health issues and their appropriate management is of greater importance to improving patient's quality of life. The persistence, sequelae and other medical complications that normally last from weeks to months after the recovery of the initial infection are involved with COVID-19. A multi-disciplinary approach is necessary for the development of preventive measures, techniques for rehabilitation and strategies for clinical management when it comes to long-term care.

摘要

大流行 COVID-19(冠状病毒病 2019)是由严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)引起的,它摧毁了全球经济和医疗保健系统。这种感染导致 COVID-19 患者数量出人意料地增加,并在全球范围内提高了死亡率。本研究全面介绍了宿主-病原体相互作用、对 COVID-19 的免疫反应、感染的恢复状况、靶向器官和相关并发症,以及康复患者和未感染者感染后免疫的比较。变异的出现和 COVID-19 感染的爆发使情况恶化。及时推出疫苗和预防措施有助于控制感染的严重程度。后来,从 COVID-19 中康复的人群显著增加。然而,了解感染后产生的医疗保健问题的影响对于改善个人的健康状况至关重要。现在人们认识到,COVID-19 感染会影响多个器官,并表现出广泛的临床表现。因此,COVID-19 感染会使已经存在健康并发症的个体面临更高的风险。确定与 COVID-19 相关的健康问题及其适当管理对于提高患者的生活质量更为重要。COVID-19 感染后的持续存在、后遗症和其他通常在初始感染恢复后持续数周到数月的医疗并发症涉及到 COVID-19。在长期护理方面,需要采取多学科方法来制定预防措施、康复技术和临床管理策略。

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Long COVID: major findings, mechanisms and recommendations.长新冠:主要发现、机制和建议。
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Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection.原发感染 6 个月后仍能保持对 SARS-CoV-2 的特异性 T 细胞免疫。
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Six-month Follow-up Chest CT Findings after Severe COVID-19 Pneumonia.重症 COVID-19 肺炎患者 6 个月随访的胸部 CT 结果。
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6-month consequences of COVID-19 in patients discharged from hospital: a cohort study.新冠肺炎出院患者 6 个月的后果:一项队列研究。
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