Raptopoulos V, Davis M A, Smith E H
Invest Radiol. 1986 Nov;21(11):847-50. doi: 10.1097/00004424-198611000-00003.
In this study, we reassessed the problems encountered in computed tomographic (CT) examinations performed with conventional bowel preparations, and developed a fat density oral contrast in dogs. Conventional high-density agents, water, fat (negative) density, and air were administered using a nasogastric tube to eight dogs (25 separate CT scans). Optimal and consistent identification of the gastrointestinal (GI) tract and mural visualization were achieved with 400 ml of 12.5% to 50% corn oil emulsions administered in four hourly divided doses. Mild diarrhea was observed with the 50% concentration only, but no untoward effect was noted clinically with 25% and 12.5% emulsions. Mixing the negative (fat) density oral contrast with the GI contents produced conditions optimal for high-CT contrast resolution of the GI wall. Standard intravenous administration of iodinated contrast agent enhanced mural visualization and, in conjunction with dynamic scanning, time density curves. This suggests that vascular perfusion could be portrayed. This animal model may be used for the experimental evaluation of a number of GI abnormalities, including ischemic, neoplastic, and inflammatory conditions.
在本研究中，我们重新评估了使用传统肠道准备进行计算机断层扫描（CT）检查时遇到的问题，并研发了一种犬用脂肪密度口服造影剂。通过鼻胃管向8只犬（25次单独的CT扫描）给予传统的高密度造影剂、水、脂肪（阴性）密度造影剂和空气。以每小时分4次给予400毫升12.5%至50%玉米油乳剂的方式，实现了对胃肠道（GI）的最佳且一致的识别以及肠壁显影。仅在50%浓度时观察到轻度腹泻，但25%和12.5%乳剂在临床上未观察到不良影响。将阴性（脂肪）密度口服造影剂与胃肠道内容物混合，产生了有利于胃肠道壁高CT对比分辨率的条件。标准静脉注射碘化造影剂增强了肠壁显影，并结合动态扫描生成了时间密度曲线。这表明可以描绘血管灌注情况。该动物模型可用于多种胃肠道异常的实验评估，包括缺血性、肿瘤性和炎症性疾病。
