Kawasoe Chihiro, Miyamoto Yoshi, Ito Kaoru, Murashima Takaya, Nagai Takahiro, Takamori Hiroki, Kiwaki Takumi, Kamimura Toshio, Mukai Shoichiro, Kamoto Toshiyuki
Department of Urology, Faculty of Medicine, Miyazaki University Hospital, Miyazaki, Japan.
Department of Urology, Koga General Hospital, Miyazaki, Japan.
Res Rep Urol. 2023 Oct 5;15:447-452. doi: 10.2147/RRU.S425887. eCollection 2023.
Epithelioid angiomyolipoma (EAML) is a rare variant of AML with malignant potential. It is occasionally difficult to distinguish EAML from renal cell carcinoma (RCC) on imaging. A 72-year-old woman was admitted to our hospital for the treatment of a left renal tumor with relatively high blood flow and a tumor thrombus extending to the inferior vena cava, suggesting RCC. The patient underwent presurgical combination therapy with axitinib and pembrolizumab. This treatment significantly shortened the thrombus, and radical nephrectomy was performed. The pathological findings were compatible with EAML, and the treatment effects were observed. We report a case treated pre-surgically with a combined therapy of pembrolizumab and axitinib, with a favorable response as a treatment option for EAML.
上皮样血管平滑肌脂肪瘤（EAML）是一种具有恶性潜能的罕见的AML变异型。在影像学上，有时很难将EAML与肾细胞癌（RCC）区分开来。一名72岁女性因治疗左肾肿瘤入院，该肿瘤血流相对较高，且肿瘤血栓延伸至下腔静脉，提示为RCC。患者接受了阿昔替尼和帕博利珠单抗的术前联合治疗。这种治疗显著缩短了血栓，随后进行了根治性肾切除术。病理结果与EAML相符，并观察到了治疗效果。我们报告了一例术前接受帕博利珠单抗和阿昔替尼联合治疗的病例，该联合治疗作为EAML的一种治疗选择具有良好的反应。
