Zhang X Y, He D M
Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2023 Oct 9;58(10):1077-1082. doi: 10.3760/cma.j.cn112144-20230817-00096.
Temporomandibular joint osteoarthritis (TMJOA) is a kind of degenerative lesion in temporomandibular joint disorders. The pathogenesis of TMJOA is complex. Among them, excessive mechanical stress plays an important role, which can cause a series of pathological changes, including synovial inflammation, chondrocyte death, osteogenic and adipogenic differentiation, degradation of extracellular matrix of cartilage, angiogenesis, osteochondral interface sclerosis, subchondral bone remodeling, degeneration of articular discs, etc. In the pathogenesis of TMJOA, it involves multiple signal pathways and epigenetic regulation, which may become potential therapeutic targets of TMJOA. In this paper, the research progress on the pathologic mechanism of TMJOA in recent years is reviewed to provide a basis for finding new therapeutic targets of TMJOA.
颞下颌关节骨关节炎（TMJOA）是颞下颌关节紊乱病中的一种退行性病变。TMJOA的发病机制复杂。其中，过度的机械应力起重要作用，可引起一系列病理变化，包括滑膜炎、软骨细胞死亡、成骨和成脂分化、软骨细胞外基质降解、血管生成、骨软骨界面硬化、软骨下骨重塑、关节盘退变等。在TMJOA的发病机制中，涉及多种信号通路和表观遗传调控，这可能成为TMJOA潜在的治疗靶点。本文综述近年来TMJOA病理机制的研究进展，为寻找TMJOA新的治疗靶点提供依据。
