Department of Orthodontics, Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Chongqing Key Laboratory of Oral Disease and Biomedical Sciences, and Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Stem Cells Dev. 2022 Aug;31(15-16):445-459. doi: 10.1089/scd.2021.0324. Epub 2022 Feb 18.
The high prevalence of temporomandibular joint osteoarthritis (TMJOA), which causes joint dysfunction, indicates the need for more effective methods for treatment and repair. Mandibular condylar cartilage (MCC), a typical fibrocartilage that experiences degenerative changes during the development of TMJOA, has become a research focus and therapeutic target in recent years. MCC is composed of four zones of cells at various stages of differentiation. The cell subsets in MCC exhibit different physiological and pathological characteristics during development and in TMJOA. Most studies of TMJOA are mainly concerned with gene regulation of pathological changes. The corresponding treatment targets with specific cell subsets in MCC may provide more accurate and reliable results for cartilage repair and TMJOA treatment. In this review, we summarized the current research progress on the cell subsets of MCC from the perspective of MCC development and degeneration. We hope to provide a reference for further exploration of the pathological process of TMJOA and improvement of TMJOA treatment.
颞下颌关节骨关节炎（TMJOA）患病率较高，可导致关节功能障碍，这表明需要更有效的治疗和修复方法。下颌髁突软骨（MCC）是一种典型的纤维软骨，在 TMJOA 的发展过程中会发生退行性变化，近年来已成为研究焦点和治疗靶点。MCC 由处于不同分化阶段的四个细胞区带组成。在发育过程中和 TMJOA 中，MCC 中的细胞亚群表现出不同的生理和病理特征。大多数 TMJOA 的研究主要关注基因调控的病理变化。MCC 中特定细胞亚群的相应治疗靶点可能为软骨修复和 TMJOA 治疗提供更准确、更可靠的结果。在这篇综述中，我们从 MCC 发育和退变的角度总结了 MCC 细胞亚群的研究进展。我们希望为进一步探讨 TMJOA 的病理过程和改善 TMJOA 的治疗提供参考。
